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GENETICS

A polygenic score predicts CKD across ancestries

Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries.

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Fig. 1: Construction and use of polygenic scores.

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Acknowledgements

The work of A.K. was supported by German Research Foundation (DFG) Project ID 431984000-SFB 1453.

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Correspondence to Anna Köttgen.

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The authors declare no competing interests.

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Steinbrenner, I., Köttgen, A. A polygenic score predicts CKD across ancestries. Nat Rev Nephrol (2022). https://doi.org/10.1038/s41581-022-00622-8

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  • DOI: https://doi.org/10.1038/s41581-022-00622-8

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