Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries.
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Acknowledgements
The work of A.K. was supported by German Research Foundation (DFG) Project ID 431984000-SFB 1453.
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Steinbrenner, I., Köttgen, A. A polygenic score predicts CKD across ancestries. Nat Rev Nephrol 18, 681–682 (2022). https://doi.org/10.1038/s41581-022-00622-8
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DOI: https://doi.org/10.1038/s41581-022-00622-8
