The most common treatment option worldwide for persons with kidney failure is in-centre haemodialysis; however, this treatment has remained largely unchanged over decades owing to a lack of true patient-centred technological innovation. The development of safe and effective wearable forms of dialysis has the potential to transform the lives of these patients.
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References
Himmelfarb, J. & Ikizler, T. A. Hemodialysis. N Engl. J. Med. 363, 1833–1845 (2010).
Ash, S. R. Sorbents in treatment of uremia: a short history and a great future. Semin. Dial. 22, 615–622 (2009).
Meng, F. et al. MXene sorbents for removal of urea from dialysate: a step toward the wearable artificial kidney. ACS Nano 12, 10518–10528 (2018).
Overbury, S. H. et al. Complexity of intercalation in MXenes: destabilization of urea by two-dimensional titanium carbide. J. Am. Chem. Soc. 140, 10305–10314 (2018).
Gura, V. et al. A wearable artificial kidney for patients with end-stage renal disease. JCI Insight 1, e86397 (2016).
van Gelder, M. K. et al. Urea removal strategies for dialysate regeneration in a wearable artificial kidney. Biomaterials 234, 119735 (2020).
Shao, G., Zang, Y. & Hinds, B. J. TiO2 nanowires based system for urea photodecomposition and dialysate regeneration. ACS Appl. Nano Mater. 2, 6116–6123 (2019).
Harker, L. A. & Slichter, S. J. Platelet and fibrinogen consumption in man. N. Engl. J. Med. 287, 999–1005 (1972).
Zhang, Z. et al. Blood compatibility of surfaces with superlow protein adsorption. Biomaterials 29, 4285–4291 (2008).
Kim, J. E., Kessler, L., McCauley, Z., Niiyama, I. & Boyle, L. N. Human factors considerations in designing a personalized mobile dialysis device: an interview study. Appl. Ergon. 85, 103003 (2020).
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J.H. and B.R. are founders of and hold equity in AKTIV-X Technologies, Inc.
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Himmelfarb, J., Ratner, B. Wearable artificial kidney: problems, progress and prospects. Nat Rev Nephrol 16, 558–559 (2020). https://doi.org/10.1038/s41581-020-0318-1
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DOI: https://doi.org/10.1038/s41581-020-0318-1
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