Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ACUTE KIDNEY INJURY

SuPAR: a potential predictive biomarker for acute kidney injury

New data suggest that plasma soluble urokinase receptor (suPAR) might be a predictive biomarker and potential therapeutic target for acute kidney injury (AKI). However, many questions remain regarding the potential of suPAR to inform clinical decision making, identify patients for enrolment in clinical trials and add to the understanding of AKI pathogenesis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hayek, S. S. et al. Soluble urokinase receptor and acute kidney injury. N. Engl. J. Med. 382, 416–426 (2020).

    Article  CAS  Google Scholar 

  2. American Society of Nephrology Renal Research Report. J. Am. Soc. Nephrol. 16, 1886–1903 (2005).

  3. Griffin, B. R., Gist, K. M. & Faubel, S. Current status of novel biomarkers for the diagnosis of acute kidney injury: a historical perspective. J. Intensive Care Med. 35, 415–424 (2020).

    Article  Google Scholar 

  4. Zarbock, A. et al. Effect of early versus delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN Randomized Clinical Trial. JAMA 315, 2190–2199 (2016).

    Article  CAS  Google Scholar 

  5. Endre, Z. H. et al. Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int. 77, 1020–1030 (2010).

    Article  CAS  Google Scholar 

  6. Meersch, M. et al. Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Med. 43, 1551–1561 (2017).

    Article  CAS  Google Scholar 

  7. Goldstein, S. L. et al. A prospective multi-center quality improvement initiative (NINJA) indicates a reduction in nephrotoxic acute kidney injury in hospitalized children. Kidney Int. 97, 580–588 (2020).

    Article  CAS  Google Scholar 

  8. Koyner, J. L., Zarbock, A., Basu, R. K. & Ronco, C. The impact of biomarkers of acute kidney injury on individual patient care. Nephrol. Dial. Transplant. https://doi.org/10.1093/ndt/gfz188 (2019).

    Article  PubMed  Google Scholar 

  9. Faubel, S. et al. Ongoing clinical trials in AKI. Clin. J. Am. Soc. Nephrol. 7, 861–873 (2012).

    Article  Google Scholar 

  10. Skrypnyk, N. I. et al. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. https://doi.org/10.1016/j.kint.2019.11.013 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sarah Faubel.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Faubel, S. SuPAR: a potential predictive biomarker for acute kidney injury. Nat Rev Nephrol 16, 375–376 (2020). https://doi.org/10.1038/s41581-020-0276-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41581-020-0276-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing