RENAL CELL CARCINOMA

Proteomic signatures of clear cell renal cell carcinoma

Article metrics

In recent years, the molecular view of clear cell renal cell carcinoma (ccRCC) has been based primarily on gene transcription data with limited information on protein features. A new study led by the Clinical Proteomic Tumor Analysis Consortium now offers a comprehensive view of the ccRCC proteome.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: CPTAC versus TCGA ccRCC proteomic data.

References

  1. 1.

    Clark, D. et al. Integrated proteogenomic characterization of clear cell renal cell carcinoma. Cell 179, 964–983 (2019).

  2. 2.

    Akbani, R. et al. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat. Commun. 5, 3887 (2014).

  3. 3.

    Zhang, Y. et al. A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations. Cancer Cell 31, 820–832 (2017).

  4. 4.

    Chen, F. et al. Multilevel genomics-based taxonomy of renal cell carcinoma. Cell Rep. 14, 2476–2489 (2016).

  5. 5.

    The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of papillary renal cell carcinoma. N. Engl. J. Med. 374, 135–145 (2015).

  6. 6.

    The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43–49 (2013).

  7. 7.

    Cancer Genome Atlas Research Network et al. The Cancer Genome Atlas pan-cancer analysis project. Nat. Genet. 45, 1113–1120 (2013).

  8. 8.

    Edwards, N. et al. The CPTAC data portal: a resource for cancer proteomics research. J. Proteome. Res. 14, 2707–2713 (2015).

  9. 9.

    Chandrashekar, D. et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia 19, 649–658 (2017).

  10. 10.

    Davis, C. et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell 26, 319–330 (2014).

Download references

Acknowledgements

This work was supported in part by National Institutes of Health (NIH) grant P30CA125123.

Author information

Correspondence to Chad J. Creighton.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Creighton, C.J. Proteomic signatures of clear cell renal cell carcinoma. Nat Rev Nephrol (2019) doi:10.1038/s41581-019-0233-5

Download citation