A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host genetic variants influence levels of the short-chain fatty acids butyrate and propionate in the gut, which in turn modulate host glycaemic metabolism.
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Acknowledgements
W.L.L. is funded by American Heart Association grant 17IRG33410803 and National Institutes of Health–National Institute of Neurological Disorders and Stroke grant R01 NS20989.
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Lau, W.L., Vaziri, N.D. Gut microbial short-chain fatty acids and the risk of diabetes. Nat Rev Nephrol 15, 389–390 (2019). https://doi.org/10.1038/s41581-019-0142-7
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DOI: https://doi.org/10.1038/s41581-019-0142-7
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