A new study reports that human blood vessel organoids can be generated through the directed differentiation of human pluripotent stem cells. Use of these blood vessel organoids to model diabetic vasculopathy led to the identification of a new potential therapeutic target, suggesting that this system could have translational value for studies of diabetes complications.
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R.M. is a co-inventor on patents (PCT/US16/52350) relating to organoid technologies that are assigned to Partners HealthCare.
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Morizane, R. Modelling diabetic vasculopathy with human vessel organoids. Nat Rev Nephrol 15, 258–260 (2019). https://doi.org/10.1038/s41581-019-0125-8
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DOI: https://doi.org/10.1038/s41581-019-0125-8
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