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Renal denervation: one step backwards, three steps forward

Nature Reviews Nephrologyvolume 14pages602604 (2018) | Download Citation

Many considered the failure of the SYMPLICITY HTN-3 trial to represent the end of therapeutic renal denervation. However, promising preliminary data from the SPYRAL HTN-OFF MED study and more recently the SPYRAL HTN-ON MED and RADIANCE-HTN SOLO studies support the efficacy of this intervention for blood pressure lowering in patients with hypertension.

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Author information


  1. Dobney Hypertension Centre, School of Medicine — Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia

    • Markus P. Schlaich
  2. Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Western Australia, Australia

    • Markus P. Schlaich
  3. Neurovascular Hypertension & Kidney Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

    • Markus P. Schlaich
  4. Comprehensive Hypertension Center, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA

    • George L. Bakris


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Competing interests

M.P.S. is supported by a National Health and Medical Research Council (NHMRC) Research Fellowship and has received consulting fees and/or travel and research support from Medtronic, Abbott, Novartis, Servier, Pfizer and Boehringer-Ingelheim. G.L.B. has acted as Consultant for Merck, Relypsa, Vascular Dynamics, Medtronic and Bayer, and has been involved in clinical trials: FIDELIO-Bayer-Principal Investigator, CREDENCE-Steering Committee and CALM-2-Executive Committee.

Corresponding author

Correspondence to Markus P. Schlaich.

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