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Cellular recording devices imprint the history of the cell

Technologies such as proteomics provide a snapshot of a specific cellular state but are unable to directly record successive signalling events. Two new CRISPR-mediated analogue multi-event recording apparatus (CAMERA) systems enable sequential recording of endogenous and exogenous signalling events by targeted DNA modifications, thereby allowing systematic interrogation of different cellular states.

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  1. 1.

    Hasin, Y., Seldin, M. & Lusis, A. Multi-omics approaches to disease. Genome Biol. 18, 83 (2017).

  2. 2.

    Tang, W. & Liu, D. R. Rewritable multi-event analog recording in bacterial and mammalian cells. Science (2018).

  3. 3.

    Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192–1205 (2012).

  4. 4.

    Schmidt-Ott, K. M. & Barasch, J. WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int. 74, 1004–1008 (2008).

  5. 5.

    Kawakami, T., Ren, S. & Duffield, J. S. Wnt signalling in kidney diseases: dual roles in renal injury and repair. J. Pathol. 229, 221–231 (2013).

  6. 6.

    Tiong, H. Y. et al. Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models. Mol. Pharm. 11, 1933–1948 (2014).

  7. 7.

    Papadimitriou, J. C. et al. BK polyomavirus infection and renourinary tumorigenesis. Am. J. Transplant. 16, 398–406 (2016).

  8. 8.

    Pfeifer, G. P. & Besaratinia, A. Mutational spectra of human cancer. Hum. Genet. 125, 493–506 (2009).

  9. 9.

    Jurado-Escobar, R. et al. Update on the genetic basis of drug hypersensitivity reactions. J. Investig. Allergol. Clin. Immunol. 27, 336–345 (2017).

  10. 10.

    Sheth, R. U., Yim, S. S., Wu, F. L. & Wang, H. H. Multiplex recording of cellular events over time on CRISPR biological tape. Science 358, 1457–1461 (2017).

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Author information


  1. Division of Nephrology, Department of Medicine, Columbia University Medical Center, Russ Berrie Pavilion, New York, NY, USA

    • Nicholas J. Steers
    •  & Ali G. Gharavi


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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Ali G. Gharavi.