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Clinical translation of nanoparticles for neural stimulation

Nature Reviews Materials volume 6, pages 1–4 (2021)Cite this article

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Nanoparticles enable wireless neural stimulation without the need for genetic manipulation. However, challenges remain for their potential application in the cure of human neurodegenerative diseases. A careful analysis of the different nanomaterials and energy sources that proved effective in animal models will direct their clinical translatability.

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Fig. 1: Strategies for neurostimulation.

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Acknowledgements

The work was supported by Fondazione Cariplo (project 2018-0505 ‘Nanosparks’), H2020-MSCA-ITN 2019 ‘Entrain Vision’ (project 861423) and EuroNanoMed3 (project 2019-132 ‘NanoLight’). The support of Fondazione 13 Marzo (Parma, Italy) is also acknowledged.

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Authors and Affiliations

  1. Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genoa, Italy

    Fabio Benfenati

  2. IRCCS Ospedale Policlinico San Martino, Genoa, Italy

    Fabio Benfenati

  3. Center for Nano Science and Technology, Istituto Italiano di Tecnologia, Milan, Italy

    Guglielmo Lanzani

  4. Department of Physics, Politecnico di Milano, Milan, Italy

    Guglielmo Lanzani

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  1. Fabio Benfenati
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  2. Guglielmo Lanzani
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Both authors contributed equally to the preparation of the manuscript

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Correspondence to Fabio Benfenati.

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The authors declare no competing interests.

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Benfenati, F., Lanzani, G. Clinical translation of nanoparticles for neural stimulation. Nat Rev Mater 6, 1–4 (2021). https://doi.org/10.1038/s41578-020-00267-8

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