As the COVID-19 vaccination programme starts to be rolled out, many young women are hesitant to accept the vaccine, citing concerns about fertility. Meanwhile, those offered the vaccine during pregnancy must decide whether they will accept, even though pregnant people were excluded from the clinical trials. Data on accidental pregnancies that occurred during the trials and, increasingly, outcomes in pregnant people who receive the vaccine can help these groups to make informed decisions.
Subscribe to Journal
Get full journal access for 1 year
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. mRNA vaccines — a new era in vaccinology. Nat. Rev. Drug Discov. 17, 261–279 (2018).
Cosma, S. et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case–control study of 225 pregnant patients. Am. J. Obstet. Gynecol. https://doi.org/10.1016/j.ajog.2020.10.005 (2020).
Lu-Culligan, A. & Iwasaki, A. The false rumours about vaccines that are scaring women. New York Times (26 Jan 2021).
United States Food & Drug Administration. Pfizer-BioNTech COVID-19 vaccine (BNT162, PF-07302048). Vaccines and related biological products advisory committee briefing document. FDA https://www.fda.gov/media/144246/download (2020).
United States Food & Drug Administration. Vaccines and related biological products advisory committee meeting December 17, 2020. FDA briefing document: Moderna COVID-19 vaccine. FDA https://www.fda.gov/media/144434/download (2020).
Medicines & Healthcare products Regulatory Agency. Public assessment report authorisation for temporary supply. COVID-19 vaccine AstraZeneca, solution for injection in multidose container COVID-19 vaccine (ChAdOx1-S [recombinant]). MHRA https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/949772/UKPAR_COVID_19_Vaccine_AstraZeneca_05.01.2021.pdf (2021).
Nunez-Smith, M. & Fauci, A. Press briefing by White House COVID-19 response team and public health officials, 10 February 2021. The White House https://www.whitehouse.gov/briefing-room/press-briefings/2021/02/10/press-briefing-by-white-house-covid-19-response-team-and-public-health-officials-3/ (2021).
Medicines & Healthcare products Regulatory Agency. Coronavirus vaccine - weekly summary of yellow card reporting. gov.uk https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting (2021).
Allotey, J. et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 370, m3320 (2020).
Gilbert, P. & Rudnick, C. Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination. Preprint at medRxiv https://doi.org/10.1101/2021.02.03.21250579 (2021).
The author declares no competing interests.
About this article
Cite this article
Male, V. Are COVID-19 vaccines safe in pregnancy?. Nat Rev Immunol 21, 200–201 (2021). https://doi.org/10.1038/s41577-021-00525-y