Passive immunization with convalescent plasma (CP) is being evaluated as a treatment for COVID-19. A multicentre, open-label, randomized, controlled trial was conducted in India in which patients received either best standard of care (BSC) (n = 229) or BSC coupled with two 200 ml doses of CP (n = 235). Despite lower viral RNA measured in patients who received CP, there was no difference in 28-day mortality or progression to severe disease between treatment arms. Importantly, 83% of study participants showed detectable neutralizing antibodies (nAbs) at enrolment and nAb titres did not change after treatment. Although this trial failed to demonstrate therapeutic efficacy, future investigations using CP pre-screened for higher nAb titres or treating nAb-naive patients may be warranted.
Agarwal, A. et al. Convalescent plasma in the management of moderate COVID-19 in India: an open-label parallel-arm phase II multicentre randomized controlled trial (PLACID Trial). Preprint at medRxiv https://doi.org/10.1101/2020.09.03.20187252 (2020)
About this article
Cite this article
Brown, M. Convalescent plasma trial shows no benefit. Nat Rev Immunol 20, 649 (2020). https://doi.org/10.1038/s41577-020-00461-3