Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Thyroid cancer

Novel assessment of epigenetic imprinting biomarkers for the diagnosis of thyroid nodules

Nature Reviews Clinical Oncology volume 20, pages 139–140 (2023)Cite this article

Subjects

Caring for individuals with thyroid nodules requires accurate estimation of their risk of thyroid cancer; however, available diagnostic tools offer only imprecise estimates. Novel biomarkers might help to clarify thyroid cancer risk and facilitate more-accurate diagnostic decision-making, although limitations in this area continue to exist.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Guth, S., Theune, U., Aberle, J., Galach, A. & Bamberger, C. M. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur. J. Clin. Invest. 39, 699–706 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. Haugen, B. R. et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26, 1–133 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Singh Ospina, N., Iñiguez-Ariza, N. M. & Castro, M. R. Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment. Br. Med. J. 368, l6670 (2020).

    Article  Google Scholar 

  4. Singh Ospina, N. et al. Physical exam in asymptomatic people drivers the detection of thyroid nodules undergoing ultrasound guided fine needle aspiration biopsy. Endocrine 54, 433–439 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. DiGennaro, C. et al. Assessing bias and limitations of clinical validation studies of molecular diagnostic tests for indeterminate thyroid nodules: systematic review and meta-analysis. Thyroid 32, 1144–1157 (2022).

    CAS  PubMed  Google Scholar 

  6. Hsiao, V. et al. Diagnostic accuracy of fine-needle biopsy in the detection of thyroid malignancy: a systematic review and meta-analysis. JAMA Surg. https://doi.org/10.1001/jamasurg.2022.4989 (2022).

    Article  PubMed  Google Scholar 

  7. Hu, T. X. et al. The effect modification of ultrasound risk classification on molecular testing in predicting the risk of malignancy in cytologically indeterminate thyroid nodules. Thyroid 32, 905–916 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Cibas, E. S. & Ali, S. Z. The 2017 Bethesda system for reporting thyroid cytopathology. Thyroid 27, 1341–1346 (2017).

    Article  PubMed  Google Scholar 

  9. Bongiovanni, M., Spitale, A., Faquin, W. C., Mazzucchelli, L. & Baloch, Z. W. The Bethesda system for reporting thyroid cytopathology: a meta-analysis. Acta Cytol. 56, 333–339 (2012).

    Article  PubMed  Google Scholar 

  10. Xu, H. et al. High diagnostic accuracy of epigenetic imprinting biomarkers in thyroid nodules. J. Clin. Oncol. https://doi.org/10.1200/JCO.22.00232 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

N.S.O. is supported by the National Cancer Institute of the US National Institutes of Health (award number K08CA248972). J.P.B. is supported by the National Cancer Institute of the US National Institutes of Health (award number R37CA272473). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine, University of Florida, Gainesville, FL, USA

    Naykky Singh Ospina

  2. Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Juan P. Brito

Authors
  1. Naykky Singh Ospina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Juan P. Brito
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Juan P. Brito.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Singh Ospina, N., Brito, J.P. Novel assessment of epigenetic imprinting biomarkers for the diagnosis of thyroid nodules. Nat Rev Clin Oncol 20, 139–140 (2023). https://doi.org/10.1038/s41571-022-00720-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41571-022-00720-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing