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IMMUNOTHERAPY

Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells ‘off the shelf’?

Nature Reviews Clinical Oncology volume 18, pages 195–196 (2021)Cite this article

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The question of whether allogeneic chimeric antigen receptor (CAR) T cells could replace autologous CAR T cell therapy has garnered considerable interest, but limited data have been available for comparisons to date. Now, Benjamin et al. have reported their experience with allogeneic anti-CD19 CAR T cells in 21 paediatric and adult patients with acute lymphoblastic leukaemia.

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Authors and Affiliations

  1. Cancer Immunotherapy Program, Cellular Therapy and Transplant Section, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Amanda M. DiNofia & Stephan A. Grupp

  2. Division of Oncology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Amanda M. DiNofia & Stephan A. Grupp

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  1. Amanda M. DiNofia
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  2. Stephan A. Grupp
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Correspondence to Stephan A. Grupp.

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Competing interests

S.A.G. has received research support from CRISPR/Vertex, Kite/Gillead, Novartis and Servier, and has been a scientific advisory board or steering committee member and/or consultant for Adaptimmune, Allogene, CBMG, Cabaletta, Cellectis, CRISPR/Vertex, GSK, Janssen/Johnson & Johnson, Juno, Jazz, Novartis, Roche and TCR2. A.D. declares no competing interests.

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DiNofia, A.M., Grupp, S.A. Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells ‘off the shelf’?. Nat Rev Clin Oncol 18, 195–196 (2021). https://doi.org/10.1038/s41571-021-00485-1

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