Effective anticancer therapies typically activate antitumour immunity, predominately mediated by T cells in the tumour microenvironment. Here, we discuss the roles of B cells and tertiary lymphoid structures in the context of chemotherapy-induced complement activation, which results in the induction of a B cell subset that modulates T cell function.
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Acknowledgements
We wish to thank Wolf H. Fridman for discussions about this topic and his review of this manuscript.
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Sautès-Fridman, C., Roumenina, L.T. B cells and complement at the forefront of chemotherapy. Nat Rev Clin Oncol 17, 393–394 (2020). https://doi.org/10.1038/s41571-020-0376-0
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DOI: https://doi.org/10.1038/s41571-020-0376-0
