The survival outcomes of the FLAURA trial support osimertinib as the new first-line standard of care for patients with EGFR-mutated advanced-stage non-small-cell lung cancer in health-care systems that can afford its cost. However, the low crossover rate is a flaw of this study. Knowledge of mechanisms of resistance to provide tailored treatment is the new challenge preventing a continued paradigm shift in this disease.
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J.R. has received fees as an advisory member for AstraZeneca, BMS, Boehringer and MSD, as a speaker from Pfizer, travel support from AstraZeneca, BMS, OSE Immunotherapeutics and Roche Genentech, and personal fees from OSE Immunotherapeutics. G.L. works at an institution that receives grant support from AstraZeneca, BMS, Merck and Roche Genentech.
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Japanese University Medical Information Network Clinical Trials Registry: https://www.umin.ac.jp/ctr/
US NIH ClinicalTrials.gov database: https://www.clinicaltrials.gov
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Remon, J., Lopes, G. Upfront osimertinib — winner takes it all?. Nat Rev Clin Oncol 17, 202–203 (2020). https://doi.org/10.1038/s41571-020-0346-6
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DOI: https://doi.org/10.1038/s41571-020-0346-6