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LUNG CANCER

MILD trial, strong confirmation of lung cancer screening efficacy

In a landmark analysis, investigators of the Multicentric Italian Lung Detection (MILD) trial have confirmed 10-year mortality reductions with lung cancer screening using low-dose helical CT (LDCT). These data complement the reduced lung cancer-specific mortality reported in the National Lung Screening Trial and reinforce the rationale for broad implementation of LDCT screening in high-risk populations.

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References

  1. Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).

    Article  Google Scholar 

  2. National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med. 365, 395–409 (2011).

    Article  Google Scholar 

  3. US Preventive Services Task Force. Lung cancer: screening. Recommendation summary. USPSTF https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/lung-cancer-screening (2013).

  4. Centers for Medicare & Medicard Services. Decision memo for screening for lung cancer with low dose computed tomography (LDCT) (CAG-00439N). CMS https://www.cms.gov/medicare-coverage-database/details/nca-decision-memo.aspx?NCAId=274 (2015).

  5. De Koning, H. et al. Effects of volume CT lung cancer screening: mortality results of the NELSON randomised-controlled population based trial [abstract]. J. Thorac. Oncol. 13, S185 (2018).

    Article  Google Scholar 

  6. Silva, M., Pastorino, U. & Sverzellati, N. Lung cancer screening with low-dose CT in Europe: strength and weakness of diverse independent screening trials. Clin. Radiol. 72, 389–400 (2017).

    Article  CAS  Google Scholar 

  7. Pastorino, U. et al. Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy. Ann. Oncol. https://doi.org/10.1093/annonc/mdz117 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Pastorino, U. et al. Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur. J. Cancer Prev. 21, 308–315 (2012).

    Article  Google Scholar 

  9. Heleno, B., Siersma, V. & Brodersen, J. Estimation of overdiagnosis of lung cancer in low-dose computed tomography screening: a secondary analysis of the Danish Lung Cancer Screening Trial. JAMA Intern. Med. 178, 1420–1422 (2018).

    Article  Google Scholar 

  10. Kovalchik, S. A. et al. Targeting of low-dose CT screening according to the risk of lung cancer death. N. Engl. J. Med. 369, 245–254 (2013).

    Article  CAS  Google Scholar 

  11. Schabath, M. B. et al. Differences in patient outcomes of prevalence, interval, and screen-detected lung cancers in the CT arm of the national lung screening trial. PLOS ONE 11, e0159880 (2016).

    Article  Google Scholar 

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Correspondence to Denise R. Aberle.

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Schabath, M.B., Aberle, D.R. MILD trial, strong confirmation of lung cancer screening efficacy. Nat Rev Clin Oncol 16, 529–530 (2019). https://doi.org/10.1038/s41571-019-0231-3

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