PapSEEK, a novel liquid-based cytology test, enabled the highly specific detection of endometrial and ovarian cancer in a retrospective study. Herein, I discuss potential applications of this tool, both for cancer screening of asymptomatic populations and for the early diagnosis of cancer in symptomatic women.
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References
Wang, Y. et al. Evaluation of liquid from the papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci. Transl. Med. 10, eaap8793 (2018).
Kinde, I. et al. Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers. Sci. Transl. Med. 5, 167ra4 (2013).
National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program. Cancer stat facts: uterine cancer. NCI SEER https://seer.cancer.gov/statfacts/html/corp.html (2018).
Cancer Research UK. Uterine cancer statistics. Cancer Research UK http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/uterine-cancer (2018).
Jacobs, I. et al. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncol. 12, 38–48 (2011).
Brown, P. O. & Palmer, C. The preclinical natural history of serous ovarian cancer: defining the target for early detection. PLoS Med. 6, e1000114 (2009).
Jacobs, I. J. et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet 387, 945–956 (2016).
Menon, U. et al. Risk algorithm using serial biomarker measurements doubles the number of screen-detected cancers compared with a single-threshold rule in the United Kingdom Collaborative Trial Of Ovarian Cancer Screening. J. Clin. Oncol. 33, 2062–2071 (2015).
Powell, C. B. Risk reducing salpingo-oophorectomy for BRCA mutation carriers: twenty years later. Gynecol. Oncol. 132, 261–263 (2014).
Kang, S. et al. CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol. 18, 53 (2017).
van Hanegem, N. et al. The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 197, 147–155 (2016).
Acknowledgements
The work of U.M. is supported by the NIHR University College London Hospitals Biomedical Research Centre.
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U.M. has stock ownership awarded by her employer (University College London) in and has received research funding from Abcodia Pvt Ltd, a company with an interest in screening and early detection of cancer.
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Menon, U. Steps towards effective gynaecological cancer screening. Nat Rev Clin Oncol 15, 538–540 (2018). https://doi.org/10.1038/s41571-018-0049-4
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DOI: https://doi.org/10.1038/s41571-018-0049-4
