Late-stage modification of peptides with photoactivatable groups often weakens their binding interaction with target proteins. Now, this challenge has been addressed using large libraries of cyclic peptides with photocrosslinkers incorporated prior to screening.
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Calvert, S.H., McGouran, J.F. Rapid capture of small peptide binders. Nat Rev Chem 7, 534–535 (2023). https://doi.org/10.1038/s41570-023-00517-7
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DOI: https://doi.org/10.1038/s41570-023-00517-7
