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Tiny but bright

Ten years ago, the engineering of a small luciferase called NanoLuc broke through a common limitation of bioluminescence. Currently the brightest known bioluminescent protein, NanoLuc’s activity has been used across a huge application range — enabling measurements in single cells and in whole living organisms.

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Fig. 1: NanoLuc’s enzymatic activity and application scope.


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Correspondence to Takeharu Nagai.

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Nagai, T., Hattori, M. Tiny but bright. Nat Rev Chem 6, 522–523 (2022).

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