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The dynamic cardiac cellular landscape: visualization by molecular imaging

Paradigm-shifting studies have revealed that the heart contains heterogeneous and dynamic immune and stromal cell populations that are crucial determinants of health and disease. Advances in molecular imaging now make it possible to non-invasively visualize the cardiac cellular landscape in humans, providing a means to guide precision therapies.

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K.J.L. is supported by grants from the National Institutes of Health (HL161185, HL150891 and HL151078), the Children’s Discovery Institute (PM-LI-2019-829), the Burroughs Welcome Fund (1014782), the Leducq Foundation (20CVD02) and by generous gifts through Washington University and Barnes Jewish Hospital. Y.L. is supported by grants from the National Institutes of Health (HL145212, HL150891, HL153436, HL151685 and EB025815).

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Correspondence to Kory J. Lavine.

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K.J.L. serves as a consultant for Implicit Biosciences and Medtronic and is the recipient of sponsored research agreements with Amgen and Novartis. K.J.L. and Y.L. have a pending patent entitled “Methods for detecting CCR2 receptors” (application number: US17/001,857).

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Lavine, K.J., Liu, Y. The dynamic cardiac cellular landscape: visualization by molecular imaging. Nat Rev Cardiol 19, 345–347 (2022).

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