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HEART FAILURE

Drug dosing for heart failure: does sex or size matter?

Nature Reviews Cardiology volume 16, pages 705–706 (2019)Cite this article

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Results from a prospective study by Santema and colleagues suggest that women with heart failure and reduced ejection fraction might need lower doses of standard heart failure drugs than men. However, this conclusion was formed on the basis of data from a small proportion of the population studied and might only be relevant to participants taking β-blockers.

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Fig. 1: Relationship between recommended HF drug dose and risk of death or hospitalization for HF3.

References

  1. Ponikowski, P. et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. J. Heart Fail. 18, 891–975 (2016).

    Article  Google Scholar 

  2. Hajahmadi, M. et al. Muscle wasting in young patients with dilated cardiomyopathy. J. Cachexia Sarcopenia Muscle 8, 542–248 (2017).

    Article  Google Scholar 

  3. Santema, B. T. et al. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. Lancet 394, 1254–1263 (2019).

    Article  CAS  Google Scholar 

  4. Voors, A. A. et al. A systems biology study to tailored treatment in chronic heart failure: rationale, design, and baseline characteristics of BIOSTAT-CHF. Eur. J. Heart Fail. 18, 716–726 (2016).

    Article  Google Scholar 

  5. Ouwerkerk, W. et al. Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study. Eur. Heart J. 38, 1883–1890 (2017).

    Article  CAS  Google Scholar 

  6. Lam, C. S. et al. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. Eur. J. Heart Fail. 15, 928–936 (2013).

    Article  Google Scholar 

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  1. IRCCS, San Raffaele Pisana, Rome, Italy

    Andrew J. S. Coats

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  1. Andrew J. S. Coats
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Correspondence to Andrew J. S. Coats.

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Coats, A.J.S. Drug dosing for heart failure: does sex or size matter?. Nat Rev Cardiol 16, 705–706 (2019). https://doi.org/10.1038/s41569-019-0298-7

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