Cardiovascular disease and cancer share several risk factors. Patients with heart failure have a higher rate of cancer than healthy control populations. Meijers and colleagues have taken this association a step further to present new evidence suggesting that, beyond simply sharing root causes, heart failure might actually cause cancer.
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References
Meijers, W. C. et al. Heart stimulates tumor growth by circulating factors. Circulation 138, 678–691 (2018).
Yang, G. D. et al. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. Int. J. Clin. Exp. Pathol. 7, 1348–1358 (2014).
Hillege, H. L. et al. Microalbuminuria is common, also in a non-diabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J. Intern. Med. 249, 519–526 (2001).
Koene, R. J. et al. Shared risk factors in cardiovascular disease and cancer. Circulation 133, 1104–1114 (2016).
Hasin, T. et al. Patients with heart failure have an increased risk of incident cancer. J. Am. Coll. Cardiol. 62, 881–886 (2013).
Banke, A. et al. Incidence of cancer in patients with chronic heart failure: a long-term follow-up study. Eur. J. Heart Fail. 18, 260–266 (2016).
Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860–867 (2002).
Aggarwal, B. B., Vijayalekshmi, R. V. & Sung, B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin. Cancer Res. 15, 425–430 (2009).
Ridker, P. M. et al. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet 390, 1833–1842 (2017).
Scafidi, P., Mistelli, T. & Bianchi, M. E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191–195 (2002).
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Richards, A.M. Can heart failure cause cancer?. Nat Rev Cardiol 16, 7–8 (2019). https://doi.org/10.1038/s41569-018-0105-x
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DOI: https://doi.org/10.1038/s41569-018-0105-x