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ATHEROSCLEROSIS

Inflammation, protection, and the problems of translation

Nature Reviews Cardiology volume 15, pages 729–730 (2018)Cite this article

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A wealth of data that culminated in a large clinical trial established that IL-1β blockade has beneficial effects in atherosclerotic cardiovascular disease. A new study in gene-targeted mice challenges this view by showing atheroprotective effects of IL-1β.

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Fig. 1: Blockade of IL-1β in atherosclerosis.

References

  1. Ridker, P. M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377, 1119–1131 (2017).

    Article  CAS  Google Scholar 

  2. Gomez, D. et al. Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Nat. Med. 24 1418–1429 (2018).

    Article  CAS  Google Scholar 

  3. De Vooght, V. et al. Choice of Mouse Strain Influences the Outcome in a Mouse Model of Chemical-Induced Asthma. PLoS ONE. 5, e12581 (2010).

    Article  Google Scholar 

  4. Vromman, A. et al. Mechanistic insights to the differential effects of interleukin-2 isoforms on experimental atherosclerosis. Atheroscler. Suppl. 32, 105 (2018).

    Article  Google Scholar 

  5. Gisterå, A. et al. Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Sci. Transl. Med. 5, 196ra100 (2013).

    Article  Google Scholar 

  6. Choudhury, R. et al. Arterial effects of canakinumab in patients with atherosclerosis and type 2 diabetes or glucose intolerance. J. Am. Coll. Cardiol. 68, 1769–1780 (2016).

    Article  CAS  Google Scholar 

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  1. Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

    Göran K. Hansson

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  1. Göran K. Hansson
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Correspondence to Göran K. Hansson.

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The author declares no competing interests.

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Hansson, G.K. Inflammation, protection, and the problems of translation. Nat Rev Cardiol 15, 729–730 (2018). https://doi.org/10.1038/s41569-018-0085-x

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