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STEM CELLS

Exercising engineered heart muscle to maturity

The immaturity of stem cell-derived cardiomyocytes has impeded their use for in vitro disease modelling, cardiotoxicity assays, and cell-replacement therapy. Ronaldson-Bouchard and colleagues report unparalleled in vitro maturation of stem cell-derived cardiomyocytes. This advance promises to unlock the translational potential of these cells.

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Fig. 1: In vitro maturation of pluripotent stem cell-derived cardiomyocytes induced by ramped intensity training.

References

  1. 1.

    Galdos, F. X. et al. Cardiac regeneration: lessons from development. Circ. Res. 120, 941–959 (2017).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. 2.

    Yang, X., Pabon, L. & Murry, C. E. Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes. Circ. Res. 114, 511–523 (2014).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. 3.

    Cho, G.-S. et al. Neonatal transplantation confers maturation of PSC-derived cardiomyocytes conducive to modeling cardiomyopathy. Cell Rep. 18, 571–582 (2017).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. 4.

    Chong, J. J. H. et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature 510, 273–277 (2014).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. 5.

    Ronaldson-Bouchard, K. et al. Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature 556, 239–243 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Parikh, S. S. et al. Thyroid and glucocorticoid hormones promote functional T-tubule development in human-induced pluripotent stem cell-derived cardiomyocytes. Circ. Res. 121, 1323–1330 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Hasenfuss, G. et al. Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species. Circ. Res. 68, 836–846 (1991).

    Article  CAS  PubMed  Google Scholar 

  8. 8.

    Shadrin, I. Y. et al. Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Nat. Commun. 8, 1825 (2017).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. 9.

    Zhang, D. et al. Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials 34, 5813–5820 (2013).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

D.Z. is supported by the National Scientific Fund of China (No.31741090). W.T.P. is supported by funding from the NIH (UG3 HL141798).

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Correspondence to William T. Pu.

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The authors declare no competing interests.

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Zhang, D., Pu, W.T. Exercising engineered heart muscle to maturity. Nat Rev Cardiol 15, 383–384 (2018). https://doi.org/10.1038/s41569-018-0032-x

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