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STEM CELLS

Exercising engineered heart muscle to maturity

Nature Reviews Cardiology volume 15, pages 383–384 (2018)Cite this article

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The immaturity of stem cell-derived cardiomyocytes has impeded their use for in vitro disease modelling, cardiotoxicity assays, and cell-replacement therapy. Ronaldson-Bouchard and colleagues report unparalleled in vitro maturation of stem cell-derived cardiomyocytes. This advance promises to unlock the translational potential of these cells.

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Fig. 1: In vitro maturation of pluripotent stem cell-derived cardiomyocytes induced by ramped intensity training.

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Acknowledgements

D.Z. is supported by the National Scientific Fund of China (No.31741090). W.T.P. is supported by funding from the NIH (UG3 HL141798).

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Authors and Affiliations

  1. College of Life Sciences, Hubei University, Wuhan, China

    Donghui Zhang

  2. Department of Cardiology, Boston Children’s Hospital, Boston, MA, USA

    William T. Pu

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  1. Donghui Zhang
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  2. William T. Pu
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Correspondence to William T. Pu.

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The authors declare no competing interests.

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Zhang, D., Pu, W.T. Exercising engineered heart muscle to maturity. Nat Rev Cardiol 15, 383–384 (2018). https://doi.org/10.1038/s41569-018-0032-x

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