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Porcine cancer models for clinical translation


Complex therapies and multimodal interventions have become the gold standard approach for many of the most aggressive tumour types. However, there is a lack of models that enable the development and clinical translation of such treatment concepts. Can porcine cancer models fill the gap?

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Fig. 1: Porcine models can fill a major gap in the translational chain of cancer research.


  1. Kalla, D., Kind, A. & Schnieke, A. Genetically engineered pigs to study cancer. Int. J. Mol. Sci. 21, 488 (2020).

    Article  CAS  Google Scholar 

  2. Pabst, R. The pig as a model for immunology research. Cell Tissue Res. 380, 287–304 (2020).

    Article  Google Scholar 

  3. Callesen, M. M. et al. A genetically inducible porcine model of intestinal cancer. Mol. Oncol. 11, 1616–1629 (2017).

    Article  CAS  Google Scholar 

  4. Flisikowska, T. et al. A porcine model of familial adenomatous polyposis. Gastroenterology 143, 1173–1175 (2012).

    Article  CAS  Google Scholar 

  5. Rogalla, S. et al. Biodegradable fluorescent nanoparticles for endoscopic detection of colorectal carcinogenesis. Adv. Funct. Mater. 29, 1904992 (2019).

    Article  CAS  Google Scholar 

  6. Hendricks-Wenger, A. et al. Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation. Sci. Rep. 11, 7584 (2021).

    Article  CAS  Google Scholar 

  7. Boas, F. E. et al. Induction and characterization of pancreatic cancer in a transgenic pig model. PloS ONE 15, e0239391 (2020).

    Article  CAS  Google Scholar 

  8. Kalla, D. et al. The missing link: Cre pigs for cancer research. Front. Oncol. 11, 755746 (2021).

    Article  Google Scholar 

  9. Wang, K. et al. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Genome Res. 27, 2061–2071 (2017).

    Article  CAS  Google Scholar 

  10. Rieblinger, B. et al. Cas9-expressing chickens and pigs as resources for genome editing in livestock. Proc. Natl Acad. Sci. USA. 118, e2022562118 (2021).

    Article  CAS  Google Scholar 

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Correspondence to Angelika Schnieke.

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The authors declare no competing interests.

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Saur, D., Schnieke, A. Porcine cancer models for clinical translation. Nat Rev Cancer 22, 375–376 (2022).

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