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Droplets take DNA by force

Single-molecule experiments can now quantify the surface forces that compete to package tethered DNA into a protein-rich condensate — providing much-needed mechanistic insight into the phase behaviour of the entangled genome in the nucleus.

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Fig. 1: Protein-mediated phase separation draws DNA strands under low tension into a droplet.


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Correspondence to Marina Feric.

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Feric, M. Droplets take DNA by force. Nat. Phys. 17, 981–982 (2021).

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