The direct detection of high-energy radiation such as X-rays and γ-rays by semiconductors at room temperature is a challenging proposition that requires remarkably pure and nearly perfect crystals. The emergence of metal halide perovskites, defect-tolerant semiconductors, is reviving hope for new materials in this field after an almost 20 year hiatus. Metal halide perovskites, which combine exceptional optoelectronic properties, versatile chemistry and simple synthesis, are challenging traditional approaches for the development of novel semiconductors for detecting hard radiation. We discuss the relevant physical properties, promising materials, fabrication techniques and device architectures for high-performance, low-cost detectors by targeting next-generation semiconductors for radiation detection. We also present a perspective on the impact of such advances in future medical imaging applications.
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Heiss, W. & Brabec, C. X-ray imaging: perovskites target X-ray detection. Nat. Photon. 10, 288–289 (2016).
Davros, W. Medical imaging principles, detectors, and electronics. Med. Phys. 36, 5374–5375 (2009).
Wei, H. & Huang, J. Halide lead perovskites for ionizing radiation detection. Nat. Commun. 10, 1066 (2019).
Hoheisel, M. & Batz, L. Requirements on amorphous semiconductors for medical X-ray detectors. Thin Solid Films 383, 132–136 (2001).
Huang, H. & Abbaszadeh, S. Recent developments of amorphous selenium-based X-ray detectors: a review. IEEE Sens. J. 20, 1694–1704 (2020).
Chen, Z., Zhu, Y. & He, Z. Intrinsic photopeak efficiency measurement and simulation for pixelated CdZnTe detector. Nucl. Instr. Meth. Phys. Res. A 980, 164501 (2020).
Yamada, K., Kawaguchi, H., Matsui, T., Okuda, T. & Ichiba, S. Structural phase transition and electrical conductivity of the perovskite CH3NH3Sn1-xPbxBr3 and CsSnBr3. Bull. Chem. Soc. Jpn 63, 2521–2525 (1990).
Stoumpos, C. C., Malliakas, C. D. & Kanatzidis, M. G. Semiconducting tin and lead iodide perovskites with organic cations: phase transitions, high mobilities, and near-infrared photoluminescent properties. Inorg. Chem. 52, 9019–9038 (2013).
Jena, A. K., Kulkarni, A. & Miyasaka, T. Halide perovskite photovoltaics: background, status, and future prospects. Chem. Rev. 119, 3036–3103 (2019).
Brenner, T. M., Egger, D. A., Kronik, L., Hodes, G. & Cahen, D. Hybrid organic–inorganic perovskites: low-cost semiconductors with intriguing charge-transport properties. Nat. Rev. Mater. 1, 15007 (2016).
Stoumpos, C. C. & Kanatzidis, M. G. Halide perovskites: poor man’s high-performance semiconductors. Adv. Mater. 28, 5778–5793 (2016).
Kojima, A., Teshima, K., Shirai, Y. & Miyasaka, T. Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. J. Am. Chem. Soc. 131, 6050–6051 (2009).
Chung, I., Lee, B., He, J., Chang, R. P. H. & Kanatzidis, M. G. All-solid-state dye-sensitized solar cells with high efficiency. Nature 485, 486–489 (2012).
Lee, M. M., Teuscher, J., Miyasaka, T., Murakami, T. N. & Snaith, H. J. Efficient hybrid solar cells based on meso-superstructured organometal halide perovskites. Science 338, 643–647 (2012).
Kim, H.-S. et al. Lead iodide perovskite sensitized all-solid-state submicron thin film mesoscopic solar cell with efficiency exceeding 9%. Sci. Rep. 2, 591 (2012).
Kovalenko, M. V., Protesescu, L. & Bodnarchuk, M. I. Properties and potential optoelectronic applications of lead halide perovskite nanocrystals. Science 358, 745–750 (2017).
Stoumpos, C. C. et al. Crystal growth of the perovskite semiconductor CsPbBr3: a new material for high-energy radiation detection. Cryst. Growth Des. 13, 2722–2727 (2013).
He, Y. et al. High spectral resolution of gamma-rays at room temperature by perovskite CsPbBr3 single crystals. Nat. Commun. 9, 1609 (2018).
Chen, Q. et al. All-inorganic perovskite nanocrystal scintillators. Nature 561, 88–93 (2018).
Knoll, G. F. Radiation Detection and Measurement (John Wiley & Sons, 2010).
Schlesinger, T. E. et al. Cadmium zinc telluride and its use as a nuclear radiation detector material. Mater. Sci. Eng. R 32, 103–189 (2001).
Klein, C. A. Bandgap dependence and related features of radiation ionization energies in semiconductors. J. Appl. Phys. 39, 2029–2038 (1968).
Yakunin, S. et al. Detection of gamma photons using solution-grown single crystals of hybrid lead halide perovskites. Nat. Photon. 10, 585–589 (2016).
Kasap, S. O. X-ray sensitivity of photoconductors: application to stabilized a-Se. J. Phys. D 33, 2853–2865 (2000).
Kabir, M. Z. & Kasap, S. O. Sensitivity of x-ray photoconductors: charge trapping and absorption-limited universal sensitivity curves. J. Vac. Sci. Technol. A 20, 1082–1086 (2002).
Hubbell, J. H. Photon mass attenuation and energy-absorption coefficients. Int. J. Appl. Radiat. Isot. 33, 1269–1290 (1982).
Wei, W. et al. Monolithic integration of hybrid perovskite single crystals with heterogenous substrate for highly sensitive X-ray imaging. Nat. Photon. 11, 315–321 (2017).
Pan, W. et al. Hot-Pressed CsPbBr3 quasi-monocrystalline film for sensitive direct X-ray detection. Adv. Mater. 31, 1904405 (2019).
Wu, H., Ge, Y., Niu, G. & Tang, J. Metal halide perovskites for X-ray detection and imaging. Matter 4, 144–163 (2021).
Johns, P. M. & Nino, J. C. Room temperature semiconductor detectors for nuclear security. J. Appl. Phys. 126, 040902 (2019).
Shockley, W. Currents to conductors induced by a moving point charge. J. Appl. Phys. 9, 635–636 (1938).
Ramo, S. Currents induced by electron motion. Proc. IRE 27, 584–585 (1939).
Zhong, H. Review of the Shockley–Ramo theorem and its application in semiconductor gamma-ray detectors. Nucl. Instr. Meth. Phys. Res. A 463, 250–267 (2001).
Liu, Z. et al. Noise sources and their limitations on the performance of compound semiconductor hard radiation detectors. Nucl. Instr. Meth. Phys. Res. A 916, 133–140 (2019).
He, Y. et al. CsPbBr3 perovskite detectors with 1.4% energy resolution for high-energy γ-rays. Nat. Photon. 15, 36–42 (2021).
Miyata, A. et al. Direct measurement of the exciton binding energy and effective masses for charge carriers in organic–inorganic tri-halide perovskites. Nat. Phys. 11, 582–587 (2015).
Kasap, S. O. et al. Progress in the science and technology of direct conversion a-Se X-ray sensors. J. Non-Cryst. Solids 299–302, 988–992 (2002).
Kim, Y. C. et al. Printable organometallic perovskite enables large-area, low-dose X-ray imaging. Nature 550, 87–91 (2017).
Fabini, D. H., Seshadri, R. & Kanatzidis, M. G. The underappreciated lone pair in halide perovskites underpins their unusual properties. MRS Bull. 45, 467–477 (2020).
Yaffe, O. et al. Local polar fluctuations in lead halide perovskite crystals. Phys. Rev. Lett. 118, 136001 (2017).
Srimath Kandada, A. R. & Silva, C. Exciton polarons in two-dimensional hybrid metal-halide perovskites. J. Phys. Chem. Lett. 11, 3173–3184 (2020).
Miyata, K. & Zhu, X. Y. Ferroelectric large polarons. Nat. Mater. 17, 379–381 (2018).
Meggiolaro, D., Ambrosio, F., Mosconi, E., Mahata, A. & De Angelis, F. Polarons in metal halide perovskites. Adv. Energy Mater. 10, 1902748 (2020).
Gao, P., Bin Mohd Yusoff, A. R. & Nazeeruddin, M. K. Dimensionality engineering of hybrid halide perovskite light absorbers. Nat. Commun. 9, 5028 (2018).
Cao, D. H., Stoumpos, C. C., Farha, O. K., Hupp, J. T. & Kanatzidis, M. G. 2D homologous perovskites as light-absorbing materials for solar cell applications. J. Am. Chem. Soc. 137, 7843–7850 (2015).
Yin, J. et al. Molecular behavior of zero-dimensional perovskites. Sci. Adv. 3, e1701793 (2017).
McCall, K. M., Stoumpos, C. C., Kostina, S. S., Kanatzidis, M. G. & Wessels, B. W. Strong electron–phonon coupling and self-trapped excitons in the defect halide perovskites A3M2I9 (A = Cs, Rb; M = Bi, Sb). Chem. Mater. 29, 4129–4145 (2017).
Zentai, G. Comparison of CMOS and a-Si flat panel imagers for X-ray imaging. In 2011 IEEE International Conference on Imaging Systems and Techniques 194–200 (IEEE, 2011).
Belev, G., Kasap, S., Rowlands, J. A., Hunter, D. & Yaffe, M. Dependence of the electrical properties of stabilized a-Se on the preparation conditions and the development of a double layer X-ray detector structure. Curr. Appl. Phys. 8, 383–387 (2008).
Kasap, S. et al. Amorphous and polycrystalline photoconductors for direct conversion flat panel X-ray image. Sensors 11, 5112–5157 (2011).
Kasap, S. et al. Amorphous selenium and its alloys from early xeroradiography to high resolution X-ray image detectors and ultrasensitive imaging tubes. Phys. Stat. Solidi B 246, 1794–1805 (2009).
Pan, W. et al. Cs2AgBiBr6 single-crystal X-ray detectors with a low detection limit. Nat. Photon. 11, 726–732 (2017).
Yin, L. et al. Controlled cooling for synthesis of Cs2AgBiBr6 single crystals and its application for X-ray detection. Adv. Opt. Mater. 7, 1900491 (2019).
Yang, B. et al. Heteroepitaxial passivation of Cs2AgBiBr6 wafers with suppressed ionic migration for X-ray imaging. Nat. Commun. 10, 1989 (2019).
Keshavarz, M. et al. Tuning the structural and optoelectronic properties of Cs2AgBiBr6 double-perovskite single crystals through alkali-metal substitution. Adv. Mater. 32, 2001878 (2020).
Yakunin, S. et al. Detection of X-ray photons by solution-processed lead halide perovskites. Nat. Photon. 9, 444–449 (2015).
Stranks, S. D. & Snaith, H. J. Metal-halide perovskites for photovoltaic and light-emitting devices. Nat. Nanotechnol. 10, 391–402 (2015).
Dong, Q. et al. Electron-hole diffusion lengths 175 μm in solution-grown CH3NH3PbI3 single crystals. Science 347, 967–970 (2015).
Saidaminov, M. I. et al. High-quality bulk hybrid perovskite single crystals within minutes by inverse temperature crystallization. Nat. Commun. 6, 7586 (2015).
Wei, H. et al. Sensitive X-ray detectors made of methylammonium lead tribromide perovskite single crystals. Nat. Photon. 10, 333–339 (2016).
Liu, Y. et al. Triple-cation and mixed-halide perovskite single crystal for high-performance X-ray imaging. Adv. Mater. 33, 2006010 (2021).
Liu, Y. et al. Multi-inch single-crystalline perovskite membrane for high-detectivity flexible photosensors. Nat. Commun. 9, 5302 (2018).
Li, H. et al. Sensitive and stable 2D perovskite single-crystal X-ray detectors enabled by a supramolecular anchor. Adv. Mater. 32, 2003790 (2020).
Zhuang, R. et al. Highly sensitive X-ray detector made of layered perovskite-like (NH4)3Bi2I9 single crystal with anisotropic response. Nat. Photon. 13, 602–608 (2019).
Xia, M. et al. Unveiling the structural descriptor of A3B2X9 perovskite derivatives toward X-ray detectors with low detection limit and high stability. Adv. Funct. Mater. 30, 1910648 (2020).
Liu, Y. et al. Inch-size 0D-structured lead-free perovskite single crystals for highly sensitive stable X-ray imaging. Matter 3, 180–196 (2020).
Zhang, Y. et al. Nucleation-controlled growth of superior lead-free perovskite Cs3Bi2I9 single-crystals for high-performance X-ray detection. Nat. Commun. 11, 2304 (2020).
Zhao, J. et al. Perovskite-filled membranes for flexible and large-area direct-conversion X-ray detector arrays. Nat. Photon. 14, 612–617 (2020).
Xu, Y. et al. Zero-dimensional Cs2TeI6 perovskite: solution-processed thick films with high X-ray sensitivity. ACS Photon. 6, 196–203 (2019).
Shrestha, S. et al. High-performance direct conversion X-ray detectors based on sintered hybrid lead triiodide perovskite wafers. Nat. Photon. 11, 436–440 (2017).
Matt, G. J. et al. Sensitive direct converting X-ray detectors utilizing crystalline CsPbBr3 perovskite films fabricated via scalable melt processing. Adv. Mater. Inter. 7, 1901575 (2020).
Hofstadter, R. Thallium halide crystal counter. Phy. Rev. 72, 1120–1121 (1947).
Hofstadter, R. Alkali halide scintillation counters. Phy. Rev. 74, 100–101 (1948).
Owens, A. Semiconductor materials and radiation detection. J. Synchrotron Rad. 13, 143–150 (2006).
Li, J. et al. Cs2PbI2Cl2, all-inorganic two-dimensional Ruddlesden–Popper mixed halide perovskite with optoelectronic response. J. Am. Chem. Soc. 140, 11085–11090 (2018).
Sun, Q. et al. Optical and electronic anisotropies in perovskitoid crystals of Cs3Bi2I9 studies of nuclear radiation detection. J. Mater. Chem. A 6, 23388–23395 (2018).
McCall, K. M. et al. α-particle detection and charge transport characteristics in the A3M2I9 defect perovskites (A = Cs, Rb; M = Bi, Sb). ACS Photon. 5, 3748–3762 (2018).
Dirin, D. N., Cherniukh, I., Yakunin, S., Shynkarenko, Y. & Kovalenko, M. V. Solution-grown CsPbBr3 perovskite single crystals for photon detection. Chem. Mater. 28, 8470–8474 (2016).
Tan, R. et al. Improved radiation sensing with methylammonium lead tribromide perovskite semiconductors. Nucl. Instr. Meth. Phys. Res. A 986, 164710 (2021).
Xu, Q. et al. Detection of charged particles with a methylammonium lead tribromide perovskite single crystal. Nucl. Instr. Meth. Phys. Res. A 848, 106–108 (2017).
Joglekar, S. G., Hammig, M. D. & Guo, L. J. High-energy photon spectroscopy using all solution-processed heterojunctioned surface-modified perovskite single crystals. ACS Appl. Mater. Interfaces 11, 33399–33408 (2019).
He, Y. et al. Resolving the energy of γ-ray photons with MAPbI3 single crystals. ACS Photon. 5, 4132–4138 (2018).
Wei, H. et al. Dopant compensation in alloyed CH3NH3PbBr3−xClx perovskite single crystals for gamma-ray spectroscopy. Nat. Mater. 16, 826–833 (2017).
He, Y. et al. Demonstration of energy-resolved γ-ray detection at room temperature by the CsPbCl3 perovskite semiconductor. J. Am. Chem. Soc. 143, 2068–2077 (2021).
Liu, X. et al. Solution-grown formamidinium hybrid perovskite (FAPbBr3) single crystals for α-particle and γ-ray detection at room temperature. ACS Appl. Mater. Interfaces 13, 15383–15390 (2021).
He, Y. et al. Perovskite CsPbBr3 single crystal detector for alpha-particle spectroscopy. Nucl. Instr. Meth. Phys. Res. A 922, 217–221 (2019).
He, Y. et al. Defect antiperovskite compounds Hg3Q2I2 (Q = S, Se, and Te) for room-temperature hard radiation detection. J. Am. Chem. Soc. 139, 7939–7951 (2017).
Lin, W. et al. TlSn2I5, a robust halide antiperovskite semiconductor for γ-ray detection at room temperature. ACS Photon. 4, 1805–1813 (2017).
Liu, M., Johnston, M. B. & Snaith, H. J. Efficient planar heterojunction perovskite solar cells by vapour deposition. Nature 501, 395–398 (2013).
Tennyson, E. M., Doherty, T. A. S. & Stranks, S. D. Heterogeneity at multiple length scales in halide perovskite semiconductors. Nat. Rev. Mater. 4, 573–587 (2019).
Medical Electrical Equipment—Characteristics of Digital X-ray Imaging Devices Vol. IEC 62220–1–1:2015 (International Electrotechnical Commission, 2015).
Medical Electrical Equipment—Dosimeters with Ionization Chambers and/or Semiconductor Detectors as Used in X-ray Diagnostic Imaging Vol. IEC 61674:2012 (International Electrotechnical Commission, 2012).
Boldyreva, A. G. et al. Unravelling the material composition effects on the gamma ray stability of lead halide perovskite solar cells: MAPbI3 breaks the records. J. Phys. Chem. Lett. 11, 2630–2636 (2020).
Pan, L., Feng, Y., Kandlakunta, P., Huang, J. & Cao, L. R. Performance of perovskite CsPbBr3 single crystal detector for gamma-ray detection. IEEE Trans. Nucl. Sci. 67, 443–449 (2020).
Capper, P. Properties of Narrow Gap Cadmium-Based Compounds (INSPEC the Institution of Electrical Engineers, 1994).
Triboulet, R. & Siffert, P. CdTe and Related Compounds; Physics, Defects, Hetero- and Nano-structures, Crystal Growth, Surfaces and Applications (Elsevier, 2009).
Ishii, M. & Kobayashi, M. Single crystals for radiation detectors. Prog. Cryst. Growth Charact. Mater. 23, 245–311 (1992).
Wang, X. et al. PIN diodes array made of perovskite single crystal for X-ray imaging. Phys. Stat. Solidi RRL 12, 1800380 (2018).
Song, J. et al. Facile strategy for facet competition management to improve the performance of perovskite single-crystal X-ray detectors. J. Phys. Chem. Lett. 11, 3529–3535 (2020).
Tian, S. et al. Co-axial silicon/perovskite heterojunction arrays for high-performance direct-conversion pixelated X-ray detectors. Nano Energy 78, 105335 (2020).
Wang, X. et al. Ultrafast ionizing radiation detection by p–n junctions made with single crystals of solution-processed perovskite. Adv. Electron. Mater. 4, 1800237 (2018).
Li, L. et al. Enhanced X-ray sensitivity of MAPbBr3 detector by tailoring the interface-states density. ACS Appl. Mater. Interfaces 11, 7522–7528 (2019).
Liu, X. et al. Charge transport behavior in solution-grown methylammonium lead tribromide perovskite single crystal using α particles. J. Phys. Chem. C 122, 14355–14361 (2018).
Ye, F. et al. High-quality cuboid CH3NH3PbI3 single crystals for high performance X-ray and photon detectors. Adv. Funct. Mater. 29, 1806984 (2019).
Li, J. et al. Rubidium doping to enhance carrier transport in CsPbBr3 single crystals for high-performance X-ray detection. ACS Appl. Mater. Interfaces 12, 989–996 (2020).
Peng, J. et al. Crystallization of CsPbBr3 single crystals in water for X-ray detection. Nat. Commun. 12, 1531 (2021).
Huang, Y. et al. A-site cation engineering for highly efficient MAPbI3 single-crystal X-ray detector. Angew. Chem. Int. Ed. 58, 17834–17842 (2019).
Li, X. et al. Three-dimensional lead iodide perovskitoid hybrids with high X-ray photoresponse. J. Am. Chem. Soc. 142, 6625–6637 (2020).
Tsai, H. et al. A sensitive and robust thin-film x-ray detector using 2D layered perovskite diodes. Sci. Adv. 6, eaay0815 (2020).
Lin, Y. et al. Unveiling the operation mechanism of layered perovskite solar cells. Nat. Commun. 10, 1008 (2019).
Ji, C. et al. 2D hybrid perovskite ferroelectric enables highly sensitive X-ray detection with low driving voltage. Adv. Funct. Mater. 30, 1905529 (2020).
Shen, Y. et al. Centimeter-sized single crystal of two-dimensional halide perovskites incorporating straight-chain symmetric diammonium ion for X-ray detection. Angew. Chem. Int. Ed. 59, 14896–14902 (2020).
Xu, Z. et al. Exploring lead-free hybrid double perovskite crystals of (BA)2CsAgBiBr7 with large mobility-lifetime product toward X-ray detection. Angew. Chem. Int. Ed. 58, 15757–15761 (2019).
Li, X. et al. Lead-free halide perovskite Cs3Bi2Br9 single crystals for high-performance X-ray detection. Sci. China Mater. 64, 1427–1436 (2021).
Zhang, B.-B. et al. High-performance X-ray detection based on one-dimensional inorganic halide perovskite CsPbI3. J. Phys. Chem. Lett. 11, 432–437 (2020).
Yao, L. et al. Bismuth halide perovskite derivatives for direct X-ray detection. J. Mater. Chem. C 8, 1239–1243 (2020).
Xiao, B. et al. Melt-grown large-sized Cs2TeI6 crystals for X-ray detection. CrystEngComm 22, 5130–5136 (2020).
Zheng, X. et al. Ultrasensitive and stable X-ray detection using zero-dimensional lead-free perovskites. J. Energy Chem. 49, 299–306 (2020).
Schieber, M. et al. Thick films of X-ray polycrystalline mercuric iodide detectors. J. Cryst. Growth 225, 118–123 (2001).
Cherry, S. R., Sorenson, J. & Phelps, M. Physics in Nuclear Medicine (Elsevier, 2012).
Cates, J. & Levin, C. Realizing PET systems with 100 ps FWHM coincidence timing resolution (conference presentation). Proc. SPIE 9969, 99690H(2016).
Ito, T. et al. Experimental evaluation of the GE NM/CT 870 CZT clinical SPECT system equipped with WEHR and MEHRS collimator. J. Appl. Clin. Med. Phys. 22, 165–177 (2021).
NM/CT 870 CZT (GE Healthcare, 2018); https://www.gehealthcare.com/products/molecular-imaging/nuclear-medicine/nm-ct-870-czt
Willemink, M. J., Persson, M., Pourmorteza, A., Pelc, N. J. & Fleischmann, D. Photon-counting CT: technical principles and clinical prospects. Radiology 289, 293–312 (2018).
Y.H. acknowledges support from the Research Fund from Soochow University (grant number NH12800621) and the State Key Laboratory of Radiation Medicine and Protection (grant number MZ12800121). M.G.K. acknowledges support from the Defense Threat Reduction Agency (DTRA) as part of the Interaction of Ionizing Radiation with Matter University Research Alliance (IIRM-URA) under contract number HDTRA1-20-2-0002.
Y.H. and M.G.K. are involved in a newly founded startup company called Actinia whose aim is to commercialize halide perovskites as γ-ray and X-ray detectors.
Peer review information Nature Photonics thanks Wolfgang Heiss, Kris Iniewski, Sergii Yakunin and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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He, Y., Hadar, I. & Kanatzidis, M.G. Detecting ionizing radiation using halide perovskite semiconductors processed through solution and alternative methods. Nat. Photon. 16, 14–26 (2022). https://doi.org/10.1038/s41566-021-00909-5