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Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Nature Microbiology volume 9, pages 1–3 (2024)Cite this article

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In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development.

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Fig. 1: Revitalizing antibiotic discovery through in vitro modelling of in-patient infection conditions.

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Acknowledgements

This work was supported by the National Centre of Competence in Research AntiResist funded by the Swiss National Science Foundation (grant number 180541).

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Authors and Affiliations

  1. Biozentrum, University of Basel, Basel, Switzerland

    Julie Sollier, Marek Basler, Knut Drescher, Sebastian Hiller, Richard A. Neher, Erik van Nimwegen, Dirk Bumann, Urs Jenal & Christoph Dehio

  2. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

    Petr Broz

  3. Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

    Petra S. Dittrich, Andreas Hierlemann & Sven Panke

  4. Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

    Adrian Egli

  5. Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

    Alexander Harms

  6. Department of Biomedicine, University Basel, Basel, Switzerland

    Carolyn G. King, Mattia Zampieri & Nina Khanna

  7. School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    John D. McKinney & Alexandre Persat

  8. Department of Health Policy and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Jacob Moran-Gilad

  9. Malcolm Page GmbH, Basel, Switzerland

    Malcolm G. P. Page

  10. Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland

    Paola Picotti & Uwe Sauer

  11. Laboratory Medicine, University Hospital Basel, Basel, Switzerland

    Katharina M. Rentsch

  12. Department of Chemistry, University of Zurich, Zurich, Switzerland

    Pablo Rivera-Fuentes

  13. Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland

    Daiana Stolz

  14. Department of Pneumology, University Medical Center, Freiburg, Germany

    Daiana Stolz

  15. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

    Sarah Tschudin-Sutter & Nina Khanna

  16. Department of Clinical Research, University Hospital Basel, Basel, Switzerland

    Sarah Tschudin-Sutter & Nina Khanna

  17. University Hospitals Geneva, Geneva, Switzerland

    Christian van Delden

  18. Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

    Jan-Willem Veening

  19. Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

    Annelies S. Zinkernagel

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  1. Julie Sollier
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  28. Nina Khanna
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  29. Dirk Bumann
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  30. Urs Jenal
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  31. Christoph Dehio
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Contributions

J.S., M.P., D.B., U.J. and C.D. wrote the paper and prepared the figure, with input from all authors.

Corresponding author

Correspondence to Christoph Dehio.

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The authors declare no competing interests.

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Nature Microbiology thanks Ruggero La Rosa and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Sollier, J., Basler, M., Broz, P. et al. Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nat Microbiol 9, 1–3 (2024). https://doi.org/10.1038/s41564-023-01566-w

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