Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biofilms

Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa drives heterogeneity of cyclic di-GMP signalling in biofilms as a division-of-labour strategy to maximize colonization and dispersal using the protein HecE.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The HecRE molecular switch regulates P. aeruginosa biofilm development and heterogeneity through c-di-GMP.

References

  1. Pernal, S. F. Vet. Clin. North Am. Food Anim. Pract. 37, 387–400 (2021).

    Article  PubMed  Google Scholar 

  2. Nakahashi, W. & Feldman, M. W. J. Theor. Biol. 348, 65–79 (2014).

    Article  PubMed  Google Scholar 

  3. Muñoz-Dorado, J., Marcos-Torres, F. J., García-Bravo, E., Moraleda-Muñoz, A. & Pérez, J. Front. Microbiol. 7, 781 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  4. van Gestel, J., Vlamakis, H. & Kolter, R. PLoS Biol. 13, e1002141 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Rossetti, V. & Bagheri, H. C. Proc. R. Soc. B Biol. Sci. 279, 3457–3466 (2012).

    Article  Google Scholar 

  6. Manner, C. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01403-0 (2023).

    Article  PubMed  Google Scholar 

  7. Jenal, U., Reinders, A. & Lori, C. Nat. Rev. Microbiol. 15, 271–284 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Laventie, B.-J. et al. Cell Host Microbe 25, 140–152.e6 (2019).

    Article  CAS  PubMed  Google Scholar 

  9. Malone, J. G. et al. PLoS Pathog. 6, e1000804 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by National Institutes of Health (NIH) grants GM139537 and AI58433 to C.M.W.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher M. Waters.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gomez, J.B., Waters, C.M. Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms. Nat Microbiol 8, 1380–1381 (2023). https://doi.org/10.1038/s41564-023-01428-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-023-01428-5

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology