Colonoids derived from adult human stem cells support growth of human enterovirus. Instead of spreading through the epithelium or lysing infected cells, virus is released within intact infected cells. Infected cells are detected by force-sensing ion channels, a mechanism akin to that used for normal turnover of uninfected epithelia.
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This is a summary of: Moshiri, J. et al. Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01339-5 (2023).
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Live cells infected with Enterovirus A71 are specifically extruded from human colonoids. Nat Microbiol 8, 565–566 (2023). https://doi.org/10.1038/s41564-023-01340-y