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CD8+ T cell depletion does not induce an expansion of viral reservoir in HIV model

Nature Microbiology volume 8, pages 191–192 (2023)Cite this article

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Cytotoxic CD8+ T cells reduce the average lifespan of productively infected cells during acute simian immunodeficiency virus infection (a primate model of human immunodeficiency virus infection). However, they are ineffective at preventing the establishment of a persistent reservoir of latently infected cells under long-term antiretroviral therapy.

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Fig. 1: Establishment of the SIV reservoir is independent of cytolytic T cell control.

References

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This is a summary of: Statzu, M. et al. CD8+ lymphocytes do not impact SIV reservoir establishment under ART. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01311-9 (2023).

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CD8+ T cell depletion does not induce an expansion of viral reservoir in HIV model. Nat Microbiol 8, 191–192 (2023). https://doi.org/10.1038/s41564-023-01321-1

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