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Fast track to mutualism

Rapid experimental evolution and targeted genetic engineering of Escherichia coli in a stinkbug host reveals that a single mutation can produce a host-beneficial symbiosis.

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Fig. 1: Engineering a new host-beneficial symbiosis.


  1. Koga, R. et al. Nat. Microbiol. (2022).

    Article  Google Scholar 

  2. Lenski, R. E. & Travisano, M. Proc. Natl Acad. Sci. USA 91, 6808–6814 (1994).

    Article  CAS  Google Scholar 

  3. Schulte, R. D., Makus, C., Hasert, B., Michiels, N. K. & Schulenburg, H. Proc. Natl Acad. Sci. USA 107, 7359–7364 (2010).

    Article  CAS  Google Scholar 

  4. Hoang, K. L., Morran, L. T. & Gerardo, N. M. Front. Microbiol. 7, 16 (2016).

    Google Scholar 

  5. King, K. C. et al. ISME J. 10, 1915–1924 (2016).

    Article  CAS  Google Scholar 

  6. Hosokawa, T. et al. Nat. Microbiol. 1, 15011 (2016).

    Article  CAS  Google Scholar 

  7. Tenaillon, O. et al. Nature 536, 165–170 (2016).

    Article  CAS  Google Scholar 

  8. Kaiwa, N. et al. Curr. Biol. 24, 2465–2470 (2014).

    Article  CAS  Google Scholar 

  9. Salem, H. et al. Proc. R. Soc. B 281, 20141838 (2014).

    Article  Google Scholar 

  10. McCutcheon, J. P., Boyd, B. M. & Dale, C. Curr. Biol. 29, R485–R495 (2019).

    Article  CAS  Google Scholar 

Download references


I thank A. Vigneron for valuable comments on the manuscript and gratefully acknowledge financial support from the Max Planck Society and through a Consolidator Grant from the European Research Council (ERC CoG 819585 “SYMBeetle”).

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Correspondence to Martin Kaltenpoth.

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Kaltenpoth, M. Fast track to mutualism. Nat Microbiol 7, 1104–1105 (2022).

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