Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CLINICAL MICROBIOLOGY

A powerful, non-invasive test to rule out infection

Rapid diagnostic tests capable of detecting any potential pathogen are needed to improve the efficacy of antimicrobial therapy and inform antimicrobial stewardship efforts. A new metagenomics-based test that detects microbial DNA in human blood can identify a diverse array of pathogens from any source in the body.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Metagenomic detection of microbial cfDNA for infection diagnosis.

References

  1. Blawukamp, T. A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0349-6 (2019).

    Article  Google Scholar 

  2. Fernández-Carballo, B. L. et al. Preprint at: https://jcm.asm.org/content/early/2018/11/02/JCM.01234-18.long (2018).

  3. Hong, D. K. et al. Diagn Micr. Infec. Dis. 92, 210–213 (2018).

    Article  CAS  Google Scholar 

  4. Grumaz, S. et al. Genome Med. 8, 73 (2016).

    Article  Google Scholar 

  5. Long, Y. et al. Arch. Med. Res. 47, 365–371 (2016).

    Article  CAS  Google Scholar 

  6. Green, C. et al. Lancet Infect. Dis. 9, 505–11 (2009).

    Article  CAS  Google Scholar 

  7. Zehr, L. Karius diagnostic test enabling precision medicine for infectious diseases. BioTuesdays http://bit.ly/2TluNuQ (2019).

  8. Parize, P. et al. Clin. Microbiol. Infect. 23, 574.e1–574.e6 (2017).

    Article  CAS  Google Scholar 

  9. Greninger, A. L. et al. Genome Med. 7, 99 (2015).

    Article  Google Scholar 

  10. Charalampous, T. et al. Preprint at: https://www.biorxiv.org/content/10.1101/387548v1 (2018).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Justin O’Grady.

Ethics declarations

Competing interests

J.O'G. received free sequencing consumables, expenses for conference attendance and research funding from Oxford Nanopore Technologies.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

O’Grady, J. A powerful, non-invasive test to rule out infection. Nat Microbiol 4, 554–555 (2019). https://doi.org/10.1038/s41564-019-0424-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-019-0424-7

This article is cited by

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology