Rapid diagnostic tests capable of detecting any potential pathogen are needed to improve the efficacy of antimicrobial therapy and inform antimicrobial stewardship efforts. A new metagenomics-based test that detects microbial DNA in human blood can identify a diverse array of pathogens from any source in the body.
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References
Blawukamp, T. A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0349-6 (2019).
Fernández-Carballo, B. L. et al. Preprint at: https://jcm.asm.org/content/early/2018/11/02/JCM.01234-18.long (2018).
Hong, D. K. et al. Diagn Micr. Infec. Dis. 92, 210–213 (2018).
Grumaz, S. et al. Genome Med. 8, 73 (2016).
Long, Y. et al. Arch. Med. Res. 47, 365–371 (2016).
Green, C. et al. Lancet Infect. Dis. 9, 505–11 (2009).
Zehr, L. Karius diagnostic test enabling precision medicine for infectious diseases. BioTuesdays http://bit.ly/2TluNuQ (2019).
Parize, P. et al. Clin. Microbiol. Infect. 23, 574.e1–574.e6 (2017).
Greninger, A. L. et al. Genome Med. 7, 99 (2015).
Charalampous, T. et al. Preprint at: https://www.biorxiv.org/content/10.1101/387548v1 (2018).
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J.O'G. received free sequencing consumables, expenses for conference attendance and research funding from Oxford Nanopore Technologies.
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O’Grady, J. A powerful, non-invasive test to rule out infection. Nat Microbiol 4, 554–555 (2019). https://doi.org/10.1038/s41564-019-0424-7
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DOI: https://doi.org/10.1038/s41564-019-0424-7
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