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BACTERIAL PATHOGENESIS

Chronic infection by controlling inflammation

Molecular players involved in systemic and acute infections are relatively easy to pinpoint, whereas bacterial resilience during chronic infections remains less well understood. Pseudomonas aeruginosa encodes a quorum-regulated virulence factor, TesG, that promotes chronic lung infection by suppressing host inflammatory responses.

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Fig. 1: Model for TesG suppression of inflammation.

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Correspondence to Alain Filloux or Jane C. Davies.

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Filloux, A., Davies, J.C. Chronic infection by controlling inflammation. Nat Microbiol 4, 378–379 (2019). https://doi.org/10.1038/s41564-019-0397-6

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