Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ANTIMICROBIAL RESISTANCE

TB drug susceptibility is more than MIC

Nature Microbiology volume 3, pages 971–972 (2018)Cite this article

Subjects

Genome-wide association studies and genetic analyses have identified a clinically prevalent alteration in the Mycobacterium tuberculosis genome that rewires bacterial propionate metabolism, conditionally reduces antibiotic killing without affecting minimum inhibitory concentrations, and may drive emergence of drug resistance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: prpR, a clinically prevalent and carbon-source-dependent drug-tolerance mutation in Mtb.

References

  1. Brauner, A., Fridman, O., Gefen, O. & Balaban, N. Q. Nat. Rev. Microbiol. 14, 320–330 (2016).

    Article  CAS  Google Scholar 

  2. Hicks, N. D. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0218-3 (2018).

  3. Dolan, S. K. et al. Microbiology 164, 251–259 (2018).

    Article  CAS  Google Scholar 

  4. Fridman, O., Goldberg, A., Ronin, I., Shoresh, N. & Balaban, N. Q. Nature 513, 418–421 (2014).

    Article  CAS  Google Scholar 

  5. Van den Bergh, B. et al. Nat. Microbiol. 1, 16020 (2016).

    Article  Google Scholar 

  6. Levin, B. R. & Rozen, D. E. Nat. Rev. Microbiol. 4, 556–562 (2006).

    Article  CAS  Google Scholar 

  7. Levin-Reisman, I. et al. Science 355, 826–830 (2017).

    Article  CAS  Google Scholar 

  8. Hu, H. W. et al. Nat. Microbiol. 1, 16147 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA

    Thomas Dick & Véronique Dartois

Authors
  1. Thomas Dick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Véronique Dartois
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Thomas Dick or Véronique Dartois.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dick, T., Dartois, V. TB drug susceptibility is more than MIC. Nat Microbiol 3, 971–972 (2018). https://doi.org/10.1038/s41564-018-0226-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-018-0226-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing