Metagenomic sequencing, bioinformatic analysis and heterologous expression of an orphan biosynthetic gene cluster widely found in the environment led to the discovery and structural characterization of a novel group of calcium-dependent antibiotics hidden in plain sight.
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Lam, Y.C., Crawford, J.M. Discovering antibiotics from the global microbiome. Nat Microbiol 3, 392–393 (2018). https://doi.org/10.1038/s41564-018-0135-5
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DOI: https://doi.org/10.1038/s41564-018-0135-5