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BACTERIAL PHYSIOLOGY

CRISPRs from scratch

Nature Microbiologyvolume 3pages261262 (2018) | Download Citation

CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.

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Author information

Affiliations

  1. RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA

    • Alireza Edraki
    •  & Erik J. Sontheimer
  2. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    • Erik J. Sontheimer

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Erik J. Sontheimer.

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DOI

https://doi.org/10.1038/s41564-018-0115-9

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