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BACTERIAL PATHOGENESIS

Decoding glycan recognition by bacterial toxins

Nature Microbiology volume 3, pages 124–126 (2018)Cite this article

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Functional and structural studies highlight the remarkable evolution and features of the typhoid toxin from Salmonella Typhi. This reveals that attachment of the toxin to specific N-glycan chains accounts for its tropism for selected human tissues.

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Fig. 1: Typhoid toxin binds preferentially to Neu5Ac displayed in the context of multiantennary N-glycans.

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Authors and Affiliations

  1. Institut Cochin, Inserm U1016, CNRS UMR8104, Université Paris Descartes, Paris, France

    Sandrine Bourdoulous

  2. Institut Pasteur, Département de Microbiologie, Unité des Toxines Bactériennes, Université Paris Descartes, Paris, France

    Emmanuel Lemichez

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  1. Sandrine Bourdoulous
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  2. Emmanuel Lemichez
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Correspondence to Sandrine Bourdoulous or Emmanuel Lemichez.

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The authors declare no competing financial interests.

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Bourdoulous, S., Lemichez, E. Decoding glycan recognition by bacterial toxins. Nat Microbiol 3, 124–126 (2018). https://doi.org/10.1038/s41564-018-0107-9

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