Longnecker, R., Kieff, E. & Cohen, J. I. Fields Virology 6th edn (Lippincott Williams & Wilkins, Philadelphia, 2013).
Connolly, S. A., Jackson, J. O., Jardetzky, T. S. & Longnecker, R. Fusing structure and function: a structural view of the herpesvirus entry machinery. Nat. Rev. Microbiol. 9, 369–381 (2011).
Sathiyamoorthy, K. et al. Assembly and architecture of the EBV B cell entry triggering complex. PLoS Pathog. 10, e1004309 (2014).
Epstein, M. A., Achong, B. G. & Barr, Y. M. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1, 702–703 (1964).
Fingeroth, J. D. et al. Epstein–Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc. Natl Acad. Sci. USA 81, 4510–4514 (1984).
Wang, X., Kenyon, W. J., Li, Q., Mullberg, J. & Hutt-Fletcher, L. M. Epstein–Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. J. Virol. 72, 5552–5558 (1998).
Spriggs, M. K. et al. The extracellular domain of the Epstein–Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation. J. Virol. 70, 5557–5563 (1996).
Li, Q. et al. Epstein–Barr virus uses HLA class II as a cofactor for infection of B lymphocytes. J. Virol. 71, 4657–4662 (1997).
Mullen, M. M., Haan, K. M., Longnecker, R. & Jardetzky, T. S. Structure of the Epstein–Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1. Mol. Cell 9, 375–385 (2002).
Backovic, M., Longnecker, R. & Jardetzky, T. S. Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B. Proc. Natl Acad. Sci. USA 106, 2880–2885 (2009).
Kirschner, A. N., Sorem, J., Longnecker, R. & Jardetzky, T. S. Structure of Epstein–Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. Structure 17, 223–233 (2009).
Matsuura, H., Kirschner, A. N., Longnecker, R. & Jardetzky, T. S. Crystal structure of the Epstein–Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. Proc. Natl Acad. Sci. USA 107, 22641–22646 (2010).
Sathiyamoorthy, K. et al. Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. Nat. Commun. 7, 13557 (2016).
Chesnokova, L. S., Nishimura, S. L. & Hutt-Fletcher, L. M. Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8. Proc. Natl Acad. Sci. USA 106, 20464–20469 (2009).
Chesnokova, L. S. & Hutt-Fletcher, L. M. Fusion of Epstein–Barr virus with epithelial cells can be triggered by αvβ5 in addition to αvβ6 and αvβ8, and integrin binding triggers a conformational change in glycoproteins gHgL. J. Virol. 85, 13214–13223 (2011).
Molesworth, S. J., Lake, C. M., Borza, C. M., Turk, S. M. & Hutt-Fletcher, L. M. Epstein–Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. J. Virol. 74, 6324–6332 (2000).
Chen, J., Rowe, C. L., Jardetzky, T. S. & Longnecker, R. The KGD motif of Epstein–Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells. mBio 3, e00290–11 (2012).
Wang, X. & Hutt-Fletcher, L. M. Epstein–Barr virus lacking glycoprotein gp42 can bind to B cells but is not able to infect. J. Virol. 72, 158–163 (1998).
Chen, J., Jardetzky, T. S. & Longnecker, R. The large groove found in the gH/gL structure is an important functional domain for Epstein–Barr virus fusion. J. Virol. 87, 3620–3627 (2013).
Borza, C. M. & Hutt-Fletcher, L. M. Epstein–Barr virus recombinant lacking expression of glycoprotein gp150 infects B cells normally but is enhanced for infection of epithelial cells. J. Virol. 72, 7577–7582 (1998).
Kasahara, Y. & Yachie, A. Cell type specific infection of Epstein–Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Crit. Rev. Oncol. Hematol. 44, 283–294 (2002).
Boshoff, C. Ephrin receptor: a door to KSHV infection. Nat. Med. 18, 861–863 (2012).
Hahn, A. S. et al. The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi’s sarcoma-associated herpesvirus. Nat. Med. 18, 961–966 (2012).
Kania, A. & Klein, R. Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nat. Rev. Mol. Cell Biol. 17, 240–256 (2016).
Shao, Z., Zhang, W. F., Chen, X. M. & Shang, Z. J. Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinical outcome. Oral Oncol. 44, 1110–1117 (2008).
Shao, Z. et al. EphA2/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland. J. Oral Maxil. Surg. 71, 869–878 (2013).
Wang, D. H. et al. Geldanamycin mediates the apoptosis of gastric carcinoma cells through inhibition of EphA2 protein expression. Oncol. Rep. 32, 2429–2436 (2014).
Nakamura, R. et al. EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci. 96, 42–47 (2005).
Speck, P. & Longnecker, R. Epstein–Barr virus (EBV) infection visualized by EGFP expression demonstrates dependence on known mediators of EBV entry. Arch. Virol. 144, 1123–1137 (1999).
Hahn, A. S. & Desrosiers, R. C. Binding of the Kaposi’s sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small molecule. J. Virol. 88, 8724–8734 (2014).
Kumar, B. & Chandran, B. KSHV entry and trafficking in target cells-hijacking of cell signal pathways, actin and membrane dynamics. Viruses 8, E305 (2016).
Dutta, D. et al. EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination. PLoS Pathog. 9, e1003510 (2013).
Kirschner, A. N., Lowrey, A. S., Longnecker, R. & Jardetzky, T. S. Binding-site interactions between Epstein–Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. J. Virol. 81, 9216–9229 (2007).
Hahn, A. S. & Desrosiers, R. C. Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells and endothelial cells but not fibroblasts. PLoS Pathog. 9, e1003360 (2013).
Tugizov, S. M., Berline, J. W. & Palefsky, J. M. Epstein–Barr virus infection of polarized tongue and nasopharyngeal epithelial cells. Nat. Med. 9, 307–314 (2003).