News & Views | Published:

BIOFILMS

Phaged and confused by biofilm matrix

Bacterial biofilms fabricate an extracellular amyloid fibre network that intimately links cells together and inhibits the ability of bacteriophages to penetrate the biofilm.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Chauret, C. Virulence 6, 593–601 (2011).

  2. 2.

    Kackar, S., Suman, E. & Kotian, M. S. Indian J. Med. Microbiol. 35, 80–84 (2017).

  3. 3.

    Hara, S., Koike, I., Terauchi, K., Kamiya, H. & Tanoue, E. Mar. Ecol. Prog. Ser. 145, 269–277 (1996).

  4. 4.

    Vidakovic, L., Singh, P. K., Hartmann, R., Nadell, C. D. & Drescher, K. Nat. Microbiol. https://doi.org/10.1038/s41564-017-0050-1 (2017)

  5. 5.

    Kostakioti, M., Hadjifrangiskou, M. & Hultgren, S. J. Cold Spring Harb. Perspect. Med. 4, a010306 (2013).

  6. 6.

    Zhou, Y. et al. J. Biol. Chem. 287, 35092–35103 (2012).

  7. 7.

    DePas, W. H. et al. Proc. Natl Acad. Sci. USA 7, 2629–2634 (2012).

  8. 8.

    Serra, D. O., Richter, A. M. & Hengge, R. J. Bacteriol. 24, 5540–5554 (2013).

Download references

Author information

Competing interests

The authors declare no competing financial interests.

Correspondence to Matthew R. Chapman.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: Phage diffusion into the centre of a biofilm can be discouraged by curli-mediated cell packing.