Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biomedical hydrogels

A defensive blanket against viral infection of the lungs

A safe, inhalable formulation of mucin-interacting hydrogel microparticles creates a dense protective network in the lungs against viral infections.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Overview of the SHIELD treatment.

References

  1. Mowat, A. M. & Viney, J. L. Immunol. Rev. 156, 145–166 (1997).

    Article  CAS  Google Scholar 

  2. Gehr, P., Bachofen, M. & Weibel, E. R. Respir. Physiol. 32, 121–140 (1978).

    Article  CAS  Google Scholar 

  3. Cone, R. A. Adv. Drug Deliv. Rev. 61, 75–85 (2008).

    Article  Google Scholar 

  4. Mei, X. et al. Nat. Mater. https://doi.org/10.1038/s41563-023-01475-7 (2023).

    Article  Google Scholar 

  5. Leech, G. et al. Proc. Natl Acad. Sci. USA 119, e2119266119 (2022).

    Article  CAS  Google Scholar 

  6. Bergeron, C. & Cantin, A. M. Semin. Respir. Crit. Care Med. 40, 715–726 (2019).

    Article  Google Scholar 

  7. Carlson, T. L., Lock, J. Y. & Carrier, R. L. Annu. Rev. Biomed. Eng. 20, 197–220 (2018).

    Article  CAS  Google Scholar 

  8. Chemaly, R. F. et al. Clin. Infect. Dis. 73, e773–e781 (2021).

    Article  CAS  Google Scholar 

  9. Schimpf, U. et al. Sci. Transl Med. 14, eabm2417 (2022).

    Article  CAS  Google Scholar 

  10. Crouzier, T. et al. Adv. Mater. Interfaces 2, 1500308 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas Crouzier.

Ethics declarations

Competing interests

T.C. is co-founder, shareholder, and acting chief scientific officer of Cirqle Biomedical Contraception ApS, a company developing a contraceptive through the topical reinforcement of cervical mucus.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Crouzier, T. A defensive blanket against viral infection of the lungs. Nat. Mater. 22, 803–804 (2023). https://doi.org/10.1038/s41563-023-01594-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41563-023-01594-1

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing