Apical poles without neighbouring cells

Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

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Fig. 1: The development of hepatocyte polarity during the stages of hemi-lumen formation.


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Correspondence to Fernando Martín-Belmonte.

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Díaz-Díaz, C., Martín-Belmonte, F. Apical poles without neighbouring cells. Nat. Mater. 19, 935–937 (2020). https://doi.org/10.1038/s41563-020-0766-9

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