Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Morphological features of single cells enable accurate automated classification of cancer from non-cancer cell lines
Scientific Reports Open Access 21 December 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yang, B. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0507-0 (2019).
Wolfenson, H. et al. Nat. Cell Biol. 18, 33–42 (2016).
Farag, A. K. & Roh, E. J. Med. Res. Rev. 39, 349–385 (2019).
Stehn, J. R., Schevzov, G., O’Neill, G. M. & Gunning, P. W. Curr. Cancer Drug Targets 6, 245–256 (2006).
Hendricks, M. & Weintraub, H. Proc. Natl Acad. Sci. USA 78, 5633–5637 (1981).
Gunning, P. W. & Hardeman, E. C. Curr. Biol. 27, R8–R13 (2017).
Pathan-Chhatbar, S. et al. J. Biol. Chem. 293, 863–875 (2018).
Sao, K. et al. Mol. Biol. Cell 30, 1170–1181 (2019).
Meiring, J. C. M. et al. Curr. Biol. 28, 2331–2337 (2018).
Meiring, J. C. M. et al. J. Cell Sci. 132, jcs228916 (2019).
Desouza-Armstrong, M., Gunning, P. W. & Stehn, J. R. Cytoskeleton 74, 233–248 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
E.C.H. and P.W.G. are directors and shareholders in TroBio Therapeutics Pty Ltd, a company commercializing the use of anti-tropomyosin drugs.
Rights and permissions
About this article
Cite this article
Hardeman, E.C., Gunning, P.W. Life and death agendas of actin filaments. Nat. Mater. 19, 135–136 (2020). https://doi.org/10.1038/s41563-019-0583-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41563-019-0583-1
This article is cited by
-
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
Nature Materials (2022)
-
Morphological features of single cells enable accurate automated classification of cancer from non-cancer cell lines
Scientific Reports (2021)