NEUROSCIENCE

Brain maps of fear and anxiety

Anxiety, ‘the disease of the 21st century’, is a clinical enigma. Using virtual predators to create real-world threat scenarios, two new studies build on prior rodent-based anxiety theory to map effects of personality and decision complexity in human prefrontal cortex. We may soon have coherent neural maps of these disabling and costly psychiatric disorders.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    McNaughton, N. & Corr, P. J. Neurosci. Biobehav. Rev. 28, 285–305 (2004).

  2. 2.

    Graeff, F. G. Braz. J. Med. Biol. Res. 27, 811–829 (1994).

  3. 3.

    Fung, B. et al. Nat. Hum. Behav. https://doi.org/10.1038/s41562-019-0595-5 (2019).

  4. 4.

    Korn, C. W. & Bach, D. Nat. Hum. Behav. https://doi.org/10.1038/s41562-019-0603-9 (2019).

  5. 5.

    Gray, J.A. & McNaughton, N. The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System. 2nd ed. (Oxford University Press, 2000).

  6. 6.

    LeDoux, J. Anxious: The Modern Mind in the Age of Anxiety. (Oneworld Publications, 2015).

  7. 7.

    Blanchard, D.C. & Blanchard, R.J. in Annu. Rev. Psychol. (eds. Rosenzweig, M. K. & Porter, L. W.) 43–68 (Palo Alto, 1988).

  8. 8.

    Blanchard, R. J., Griebel, G., Henrie, J. A. & Blanchard, D. C. Neurosci. Biobehav. Rev. 21, 783–789 (1997).

  9. 9.

    Blanchard, D. C. Neurosci. Biobehav. Rev. 76 Pt A, 22–28 (2017).

  10. 10.

    Gray, J.A. The Psychology of Fear and Stress. (Weidenfeld and Nicolson, 1971).

  11. 11.

    LeDoux, J. Neuron 73, 653–676 (2012).

  12. 12.

    Mobbs, D. et al. Science 317, 1079–1083 (2007).

Download references

Author information

Correspondence to Neil McNaughton.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

McNaughton, N. Brain maps of fear and anxiety. Nat Hum Behav 3, 662–663 (2019). https://doi.org/10.1038/s41562-019-0621-7

Download citation

Further reading