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Arousal increases neural gain via the locus coeruleus–noradrenaline system in younger adults but not in older adults

Nature Human Behaviourvolume 2pages356366 (2018) | Download Citation

Abstract

In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus–noradrenaline system can implement this increased selectivity under arousal and a functional magnetic resonance imaging (fMRI) study comparing how arousal affects younger and older adults’ processing indicate that the amplification of salient stimuli and the suppression of non-salient stimuli are separate processes, with ageing affecting suppression without affecting amplification under arousal. In the fMRI study, arousal increased processing of salient stimuli and decreased processing of non-salient stimuli for younger adults. By contrast, for older adults, arousal increased processing of both low- and high-salience stimuli, generally increasing excitatory responses to visual stimuli. Older adults also showed a decline in locus coeruleus functional connectivity with frontoparietal networks that coordinate attentional selectivity. Thus, among older adults, arousal increases the potential for distraction from non-salient stimuli.

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Acknowledgements

This work was supported by grants from the National Institute on Aging RO1AG025340 awarded to M.M., JSPS KAKENHI 16H03750 and 15K21062 awarded to T.U., and JSPS KAKENHI 16H05959, 16KT0002 and 16H02053 and European Commission CIG618600 awarded to M.S. We thank C. Cho for assistance with Figs. 1 and 7. The funders had no role in the conceptualization, design, data collection, analysis, decision to publish or preparation of the manuscript.

Author information

Affiliations

  1. Department of Psychology, University of Southern California, Los Angeles, CA, USA

    • Tae-Ho Lee
    • , Steven G. Greening
    •  & Mara Mather
  2. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA

    • Tae-Ho Lee
    • , Steven G. Greening
    • , Allison Ponzio
    •  & Mara Mather
  3. Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    • Tae-Ho Lee
  4. Department of Psychology, Louisiana State University, Baton Rouge, LA, USA

    • Steven G. Greening
  5. School of Human Sciences, Takachiho University, Suginami, Tokyo, Japan

    • Taiji Ueno
  6. Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA

    • David Clewett
    •  & Mara Mather
  7. Department of Psychology, New York University, New York, NY, USA

    • David Clewett
  8. School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK

    • Michiko Sakaki

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Contributions

T.-H.L. and M.M. designed the study. T.-H.L., S.G.-G. and A.P. acquired the data. Data were analysed by T.-H.L. with S.G.-G., D.C. and M.M. Modelling was conducted by T.U. and M.S. All the authors contributed to the preparation of the manuscript.

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Mara Mather.

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