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Evolution

The population genetics of prokaryotic pangenomes

Nature Ecology & Evolution volume 8, pages 190–191 (2024)Cite this article

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Inferring the evolutionary history of prokaryotic pangenomes is complicated by the lack of a reference for neutral genetic variation. A study that uses pseudogenes as a neutral reference provides support for selection as a force that shapes pangenomes.

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Fig. 1: Pseudogenes as a neutral reference to study gene content evolution.

References

  1. Charlesworth, B., Charlesworth, D., Coyne, J. A. & Langley, C. H. Genetics 203, 1497–1503 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Welch, R. A. et al. Proc. Natl Acad. Sci. USA 99, 17020–17024 (2002).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  3. Horesh, G. et al. Microb. Genom. 7, 000499 (2021).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Douglas, G. M. & Shapiro, B. J. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-023-02268-6 (2024).

    Article  PubMed  Google Scholar 

  5. Haegeman, B. & Weitz, J. S. BMC Genomics 13, 196 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Iranzo, J., Cuesta, J. A., Manrubia, S., Katsnelson, M. I. & Koonin, E. V. Proc. Natl Acad. Sci. USA 114, E5616–E5624 (2017).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Andreani, N. A., Hesse, E. & Vos, M. ISME J. 11, 1719–1721 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bobay, L.-M. & Ochman, H. BMC Evol. Biol. 18, 153 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. McInerney, J. O., McNally, A. & O’Connell, M. J. Nat. Microbiol. 2, 17040 (2017).

    Article  CAS  Google Scholar 

  10. Vos, M. & Eyre-Walker, A. Nat. Microbiol. 2, 1576 (2017).

    Article  CAS  PubMed  Google Scholar 

  11. Shapiro, B. J. Nat. Microbiol. 2, 1574 (2017).

    Article  CAS  PubMed  Google Scholar 

  12. Domingo-Sananes, M. R. & McInerney, J. O. Trends Microbiol. 29, 493–503 (2021).

    Article  CAS  PubMed  Google Scholar 

  13. McDonald, J. H. & Kreitman, M. Nature 351, 652–654 (1991).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biosciences, Nottingham Trent University, Nottingham, UK

    Maria Rosa Domingo-Sananes & Conor J. Meehan

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  1. Maria Rosa Domingo-Sananes
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  2. Conor J. Meehan
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Correspondence to Maria Rosa Domingo-Sananes.

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The authors declare no competing interests.

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Domingo-Sananes, M.R., Meehan, C.J. The population genetics of prokaryotic pangenomes. Nat Ecol Evol 8, 190–191 (2024). https://doi.org/10.1038/s41559-023-02276-6

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