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Assessing evolutionary risks of resistance for new antimicrobial therapies

Nature Ecology & Evolution volume 3, pages 515–517 (2019)Cite this article

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New antibiotics are urgently needed to combat rising rates of resistance against all existing classes of antimicrobials. We highlight key issues that complicate the prediction of resistance evolution in the real world and outline the ways in which these can be overcome.

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Fig. 1: Real-world resistance.

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Authors and Affiliations

  1. Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, UK

    Michael A. Brockhurst & Ellie Harrison

  2. School of Life Sciences, Gibbet Hill Campus, University of Warwick, Coventry, UK

    Freya Harrison

  3. Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

    Jan-Willem Veening

  4. EMBL-EBI, Wellcome Genome Campus, Hinxton, UK

    Grace Blackwell & Zamin Iqbal

  5. Department of Zoology, University of Oxford, Oxford, UK

    Craig Maclean

Authors
  1. Michael A. Brockhurst
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  2. Freya Harrison
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  5. Grace Blackwell
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Correspondence to Michael A. Brockhurst.

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Brockhurst, M.A., Harrison, F., Veening, JW. et al. Assessing evolutionary risks of resistance for new antimicrobial therapies. Nat Ecol Evol 3, 515–517 (2019). https://doi.org/10.1038/s41559-019-0854-x

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