Single-particle cryo-electron microscopy and all-atom molecular dynamics simulations provide atomic details of ATP hydrolysis in the multimeric enzyme p97.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gutteridge, A. & Thornton, J. FEBS Letters 567, 67–73 (2004).
Erzberger, J. P. & Berger, J. M. Annu. Rev. Biophys. Biomol. Struct. 35, 93–114 (2006).
Shein, M. et al. Nat. Chem. https://doi.org/10.1038/s41557-024-01440-0 (2024).
Richly, H. et al. Cell 120, 73–84 (2005).
Rabouille, C. et al. Cell 82, 905–914 (1995).
Ju, J. S. et al. J. Cell Biol. 187, 875–888 (2009).
Banerjee, S. et al. Science 351, 871–875 (2016).
Taylor, E. W. et al. Biochem. 9, 2984–2991 (1970).
Nam, K., Pu, J. & Karplus, M. Proc. Natl. Acad. Sci. USA 111, 17851–17865 (2014).
Ma, W. & Schulten, K. J. Am. Chem. Soc. 137, 3031–3040 (2015).
Priess, M. et al. ACS Cent. Sci. 4, 1334–1343 (2018).
Fernandez-Leiro, R. & Scheres, S. H. W. Nature 537, 339–346 (2016).
Torino, S. et al. Nat. Methods 20, 1400–1408 (2023).
Guaita, M., Watters, S. C. & Loerch, S. Curr. Opin. Struct. Biol. 77, 102484 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Elghobashi-Meinhardt, N. ATP hydrolysis captured in atomic detail. Nat. Chem. 16, 306–307 (2024). https://doi.org/10.1038/s41557-024-01466-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-024-01466-4
