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Fluorescent probes

Engineering cyanine cyclizations for new fluorogenic probes

Nature Chemistry volume 16, pages 3–5 (2024)Cite this article

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As the need for specific fluorescent probes that enable high sensitivity and super-resolution imaging experiments continues to grow, it is imperative to develop new, well-characterized methods to modulate the emission of fluorophores. Now, a general platform affords visible-to-NIR fluorogenic fluorophores by engineering a simple cyclization event into cyanine dyes.

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Fig. 1: Progress toward fluorogenic rhodamines and cyanines.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA

    Quintashia D. Wilson & Ellen M. Sletten

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  1. Quintashia D. Wilson
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  2. Ellen M. Sletten
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Correspondence to Ellen M. Sletten.

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The authors declare no competing interests.

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Wilson, Q.D., Sletten, E.M. Engineering cyanine cyclizations for new fluorogenic probes. Nat. Chem. 16, 3–5 (2024). https://doi.org/10.1038/s41557-023-01408-6

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